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‘Tuftsin’: a Natural Phagocytosis Stimulating Peptide

Nature volume 228, pages 672–673 (1970)Cite this article

Abstract

WE have shown in this laboratory that a specific cell bound leucophilic γ-globulin fraction, leucokinin, is essential for maximal stimulation of the phagocytic activity of the blood neutrophilic leucocyte1,2. We now report that the whole stimulatory effect of leucokinin can be ascribed to a single peptide fragment liberated by a specific enzyme in the outer membrane of the neutrophile. We shall refer to this peptide as ‘tuftsin’ (after Tufts University) and to the enzyme as leucokininase. The peptide ‘tuftsin’ has been produced in vitro from a γ-globulin fraction, PC IV, by treatment with leucokininase. PC IV is prepared by chromatography on phosphocellulose columns3 and contains all the leucokinin activity of serum γ-globulin2.

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Authors and Affiliations

  1. Division of Protein Chemistry, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, 02111

    VICTOR A. NAJJAR & KENJI NISHIOKA

Authors
  1. VICTOR A. NAJJAR
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  2. KENJI NISHIOKA
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NAJJAR, V., NISHIOKA, K. ‘Tuftsin’: a Natural Phagocytosis Stimulating Peptide. Nature 228, 672–673 (1970). https://doi.org/10.1038/228672a0

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