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Release of Dopamine-β-hydroxylase with Norepinephrine during Cat Splenic Nerve Stimulation

Nature volume 227, pages 406–407 (1970)Cite this article

Abstract

DOPAMINE-β-HYDROXYLASE is released from the catecholamine storage vesicles of the adrenal medulla together with epinephrine1. The ratio of released catecholamine to enzyme is similar to that found in the soluble contents of these vesicles. Douglas and Poisner2 found that adenosine triphosphate (ATP) was released during such adrenal stimulation and proposed that adrenal secretion takes place by a process of exocytosis (that is, emptying of the contents of the nerve vesicles).

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References

  1. Viveros, O. H., Arqueros, L., and Kirshner, N., Life Sci., 7, 609 (1968).

    Article  CAS  Google Scholar 

  2. Douglas, W. W., and Poisner, A. M., J. Physiol., 183, 236 (1966).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Brown, G. L., and Gillespie, J. S., J. Physiol., 138, 181 (1957).

    Article  Google Scholar 

  4. Umbreit, W. W., Burris, R. H., and Stouffer, J. F., in Manometric Techniques, 149 (Burgess, Minneapolis, 1957).

    Google Scholar 

  5. Fischer, J. E., Horst, W. D., and Kopin, I. J., Brit. J. Pharmacol. Chemotherap., 24, 477 (1965).

    Article  CAS  Google Scholar 

  6. Friedman, S., and Kaufman, S., J. Biol. Chem., 240, 4763 (1965).

    CAS  PubMed  Google Scholar 

  7. Anton, A. H., and Sayre, E. D., J. Pharmacol. Exp. Therap., 138, 360 (1962).

    CAS  Google Scholar 

  8. Häggendal, J., Acta Physiol. Scand., 57, 242 (1963).

    Article  Google Scholar 

  9. Smith, A. D., de Potter, W. P., and de Schaepdryver, A. F., Arch. Intern. Pharmacodyn., 179, 495 (1969).

    CAS  Google Scholar 

  10. Kopin, I. J., Breese, G. R., Krauss, K. R., and Weise, V. K., J. Pharmacol. Exp. Therap., 161, 271 (1968).

    CAS  Google Scholar 

  11. Gewirtz, G. P., and Kopin, I. J., Fed. Proc., 28, 415 (1969).

    Google Scholar 

  12. Geffen, L. B., Livett, B. G., and Rush, R. A., J. Physiol., 204, 58P (1969).

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland, 20014

    GEORGE P. GEWIRTZ & IRWIN J. KOPIN

Authors
  1. GEORGE P. GEWIRTZ
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  2. IRWIN J. KOPIN
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GEWIRTZ, G., KOPIN, I. Release of Dopamine-β-hydroxylase with Norepinephrine during Cat Splenic Nerve Stimulation. Nature 227, 406–407 (1970). https://doi.org/10.1038/227406a0

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