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Hyperactivity in Rats bred and raised on Relatively Low Amounts of Cyclamates

Nature volume 224, pages 1326–1328 (1969)Cite this article

Abstract

CALCIUM and sodium cyclamate and the metabolite cyclohexylamme have been shown to induce chromosome breakage in human leucocytes in vitro1 and in rat spermatogomal cells in vivo2. The similarity between this type of chromosomal damage and that reported for the psychomimetic drug lysergic acid diethylamide3, as well as for caffeine when used in large doses4, suggested that the behavioural effects of cyclamate should be investigated.

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References

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Authors and Affiliations

  1. Worcester Foundation for Experimental Biology, 222 Maple Avenue, Shrewsbury, Massachusetts, 01545

    DAVID STONE & EDWARD MATALKA

  2. Worcester State Hospital, 305 Belmont Street, Worcester, Massachusetts

    DAVID STONE & JAMES RIORDAN

Authors
  1. DAVID STONE
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  2. EDWARD MATALKA
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  3. JAMES RIORDAN
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STONE, D., MATALKA, E. & RIORDAN, J. Hyperactivity in Rats bred and raised on Relatively Low Amounts of Cyclamates. Nature 224, 1326–1328 (1969). https://doi.org/10.1038/2241326a0

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  • DOI: https://doi.org/10.1038/2241326a0

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