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Stimulation of Deoxyribonucleic Acid Synthesis in the Liver Parenchymal Cells of the Intact Rat

Nature volume 223, pages 956–957 (1969)Cite this article

Abstract

ONE approach to the problem of how DNA synthesis and cell division are regulated in liver has been to try to understand how partial hepatectomy leads to regeneration of the organ. There is little information on this point although it appears that the stimulus is carried in the circulating blood1–2. Another approach has involved efforts to induce DNA replication and mitosis in intact rats. We have tried for several years to enhance the synthesis of liver DNA in unoperated animals, and report here that the injection of a mixture of two fractions of bovine serum into normal rats markedly stimulates DNA formation and mitosis in the parenchymal cells of the liver.

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References

  1. Moolten, F. L., and Bucher, N. L. R., Science, 158, 272 (1967).

    Article  ADS  CAS  Google Scholar 

  2. Lieberman, I., in Biochemistry of Cell Division (edit. by Baserga, R.) (C. C. Thomas, Springfield, Illinois, 1969).

    Google Scholar 

  3. Cohn, E. J., Strong, L. E., Hughes, jun., W. L., Mulford, D. J., Ashworth, J. N., Melin, M., and Taylor, H. L., J. Amer. Chem. Soc., 68, 459 (1946).

    Article  CAS  Google Scholar 

  4. Zamenhof, S., in Methods in Enzymology (edit. by Colowick, S. P. and Kaplan, N. O.), 3, 696 (Academic Press, New York, 1957).

    Book  Google Scholar 

  5. Burton, K., Biochem. J., 61, 473 (1955).

    Article  CAS  Google Scholar 

  6. Higgins, G. M., and Anderson, R. M., Arch. Pathol., 12, 186 (1931).

    Google Scholar 

  7. Fujioka, M., Koga, M., and Lieberman, I., J. Biol. Chem., 238, 3401 (1963).

    CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Anatomy and Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

    J. SHORT, R. ZEMEL, J. KANTA & I. LIEBERMAN

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  1. J. SHORT
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  2. R. ZEMEL
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  3. J. KANTA
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  4. I. LIEBERMAN
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SHORT, J., ZEMEL, R., KANTA, J. et al. Stimulation of Deoxyribonucleic Acid Synthesis in the Liver Parenchymal Cells of the Intact Rat. Nature 223, 956–957 (1969). https://doi.org/10.1038/223956a0

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