Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Properties and Uses of Human–Mouse Hybrid Cell Lines

Abstract

Staged reduction of the chromosome complement of human–mouse hybrid cells has made possible the identification of the chromosome bearing the human gene for thymidine kinase. Effects of human chromosomes on the growth rate of hybrid cells are examined and the possibility of making further chromosomal assignments for human autosomal genes is discussed.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Weiss, M., and Green, H., Proc. US Nat. Acad. Sci., 58, 1104 (1967).

    Article  ADS  CAS  Google Scholar 

  2. Kit, S., Dubbs, D. R., Piekarski, L. J., and Hsu, T. C., Exp. Cell Res., 31, 297 (1963).

    Article  CAS  PubMed  Google Scholar 

  3. Kit, S., Piekarski, L. J., and Dubbs, D. R., J. Mol. Biol., 6, 22 (1963).

    Article  CAS  PubMed  Google Scholar 

  4. Hayflick, L., and Moorhead, P. S., Exp. Cell Res., 25, 585 (1961).

    Article  CAS  PubMed  Google Scholar 

  5. Todaro, G. J., Wolman, S., and Green, H., J. Cell Comp. Physiol., 62, 257 (1963).

    Article  CAS  PubMed  Google Scholar 

  6. Weiss, M., Todaro, G. J., and Green, H., J. Cell Physiol., 71, 105 (1968).

    Article  CAS  PubMed  Google Scholar 

  7. Ephrussi, B., and Sorieul, S., University of Michigan Medical Bulletin, 28, 347 (1962).

    Google Scholar 

  8. Littlefield, J. W., Exp. Cell Res., 41, 190 (1966).

    Article  CAS  PubMed  Google Scholar 

  9. Ephrussi, B., Interspecific Somatic Hybrids in vitro, 2, 40 (Williams and Wilkins, 1966).

    Google Scholar 

  10. Weiss, M., and Ephrussi, B., Genetics, 54, 1095 (1966).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Yerganian, G., and Nell, M. B., Proc. US Nat. Acad. Sci., 55, 1066 (1966).

    Article  ADS  CAS  Google Scholar 

  12. Harris, H., Watkins, J. F., Campbell, G. L. M., Evans, E. P., and Ford, C. E., Nature, 207, 606 (1965).

    Article  ADS  CAS  PubMed  Google Scholar 

  13. Weiss, M., Ephrussi, B., and Scaletta, L. J., Proc. US Nat. Acad. Sci., 59, 1132 (1968).

    Article  ADS  CAS  Google Scholar 

  14. Gerald, P. S., Warner, S., Singer, J. D., Corcoran, P. A., and Umansky, I., J. Pediat., 70, 172 (1967).

    Article  CAS  PubMed  Google Scholar 

  15. Littlefield, J. W., Science, 145, 709 (1964).

    Article  ADS  CAS  PubMed  Google Scholar 

  16. Nyhan, W. L., Pesek, J., Sweetman, L., Carpenter, D. G., and Carter, C. H., Pediat. Res., 1, 5 (1967).

    Article  CAS  Google Scholar 

  17. Seegmiller, J. E., Rosenbloom, F. M., and Kelley, W. N., Science, 155, 1682 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  18. Ham, R. G., Exp. Cell Res., 29, 515 (1963).

    Article  CAS  PubMed  Google Scholar 

  19. Fischer, G. A., and Welch, A. D., Science, 126, 1018 (1957).

    Article  ADS  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

MATSUYA, Y., GREEN, H. & BASILICO, C. Properties and Uses of Human–Mouse Hybrid Cell Lines. Nature 220, 1199–1202 (1968). https://doi.org/10.1038/2201199a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2201199a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing