Abstract
SINCE the discovery of lysosomal enzymes within polymorphonuclear leucocytes there has been an ever growing tendency to attribute to these granules an important role in acute inflammation1–3. This concept has received further support from experiments in which agents known to stabilize membranes have been shown to exert an anti-inflammatory effect4–6. In addition, it has been found that a reduced number of polymorphonuclear cells leads to reduced acute inflammatory reactions7 and Arthus type reactions8. The studies by Ward and Cochrane9–12 on immunological inflammation stressing the importance of the polymorphonuclear leucocyte have often been extrapolated to non-allergic acute inflammatory states. There are, however, opposing views as to the relative importance of the polymorphonuclears in bringing about vascular changes in acute inflammation13.
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WILLOUGHBY, D., SPECTOR, W. Inflammation in Agranulocytotic Rats. Nature 219, 1258 (1968). https://doi.org/10.1038/2191258a0
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DOI: https://doi.org/10.1038/2191258a0
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