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Effects of Hydroxyurea on Development and Regeneration

Nature volume 214, pages 1132–1133 (1967)Cite this article

Abstract

HYDROXYUKEA is a potent inhibitor of DNA synthesis and mitosis1–6. It is known that it interferes with the reduction of ribonucleotides to deoxyribonucleotides1–4. It is bacteriostatic for Escherichia coli7, where it induces a reversible inhibition of DNA synthesis without affecting the synthesis of RNA and proteins. At lethal concentrations, RNA (but not protein) synthesis is inhibited8, and an additional DNA band becomes visible in ultracentrifugation diagrams9; it is possible that DNA becomes incapable of both replication and transcription.

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References

  1. Young, C. W., and Hodas, S., Science, 146, 1172 (1964).

    Article  ADS  CAS  Google Scholar 

  2. Yarbro, J. W., Kennedy, B. J., and Barnum, C. P., Proc. U.S. Nat. Acad. Sci., 53, 1083 (1965).

    Article  Google Scholar 

  3. Adams, R. L. P., Abrams, R., and Liebermann, I., J. Biol. Chem., 241, 903 (1966).

    CAS  PubMed  Google Scholar 

  4. Turner, M. K., Abrams, R., and Liebermann, I., J. Biol. Chem., 241, 5777 (1966).

    CAS  PubMed  Google Scholar 

  5. Sinclair, W., Science, 150, 1729 (1965).

    Article  ADS  CAS  Google Scholar 

  6. Kihlman, B. A., Eriksson, T., and Odmark, G., Hereditas, 55, 386 (1966).

    Article  CAS  Google Scholar 

  7. Rosenkranz, H. S., Garro, A. J., Levy, J. A., and Carr, H. S., Bioch. Biophys. Acta, 114, 501 (1966).

    CAS  Google Scholar 

  8. Rosenkranz, H. S., and Carr, H. S., J. Bacteriol., 92, 178 (1966).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Rosenkranz, H. S., Biochim. Biophys. Acta, 129, 618 (1966).

    Article  CAS  Google Scholar 

  10. Eisenberg, H. W., Van Praag, D., Rosenkranz, H. S., and Shemin, D., Biol. Bull., 129, 403 (1965).

    Google Scholar 

  11. Brachet, J., in Comprehensive Biochemistry (edit. by Florkin, M., and Stotz, E.) (Elsevier, 1967).

    Google Scholar 

  12. Heilporn-Pohl, V., and Brachet, J., Biochim. Biophys. Acta, 119, 429 (1966).

    Article  CAS  Google Scholar 

  13. Lallier, R., J. Embryol. Exper. Morphol., 14, 181 (1965).

    CAS  Google Scholar 

  14. Millonig, J., Sixth Congr. Electron Microsc. Kyoto, 345 (1966).

  15. Karasaki, S., J. Cell Biol., 31, 56A (1966).

    Google Scholar 

Download references

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Authors and Affiliations

  1. Laboratoire de Morphologie animale, Université de Bruxelles, and International Laboratory for Genetics and Biophysics, Naples

    J. BRACHET

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  1. J. BRACHET
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BRACHET, J. Effects of Hydroxyurea on Development and Regeneration. Nature 214, 1132–1133 (1967). https://doi.org/10.1038/2141132a0

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