Abstract
Penicillium sclerotigenum Yamamoto1 (CMI, 68,616) has been shown to produce griseofulvin. The fungus causes tuber rots of the Chinese yam, Dioscorea batatas. It was grown in Roux bottles in a medium containing 75 g ‘Dextrosol’, 2.9 g potassium nitrate, 5.0 g potassium dihydro-orthophosphate, 1.0 g magnesium sulphate heptahydrate, 1.0 g sodium chloride, 0.5 g ‘Difco’ yeast extract, and 1 ml. of minor element concentrate (containing 0.1 g ferrous sulphate heptahydrate, 0.015 g copper sulphate pentahydrate, 0.05 g zinc sulphate heptahydrate, 0.01 g manganese sulphate heptahydrate and 0.01 g. sodium molybdenate, in 100 ml.) made up to 1 l. with distilled water. The mycelium and broth were extracted with chloroform after 26 days growth.
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References
Yamamoto, W., Yoshitani, K., and Maeda, M., Sci. Rep. Hyogo Univ. Agric., Agric. Biol. Ser., 2, 69 (1955).
Brian, P. W., Curtis, P. J., and Hemming, H. G., Trans. Brit. Mycol. Soc., 29, 174 (1946).
Wieland, P., and Prelog, V., Helv. Chim. Acta, 30, 1028 (1947).
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CLARKE, S., MCKENZIE, M. Penicillium sclerotigenum : a New Source of Griseofulvin. Nature 213, 504–505 (1967). https://doi.org/10.1038/213504b0
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DOI: https://doi.org/10.1038/213504b0
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