Abstract
N-SUCCINYL PERIMYCIN1 is a synthetic derivative of heptaene macrolide antifungal antibiotic2. The advantage of this substance is that, unlike the original polyenes, it forms readily water soluble salts, for example, the sodium salt, which retain much of the activity of perimycin itself1,3. The critical site of action of polyenes in general is the cell membrane and the lethal effect of these substances is a result of an impairment of the membrane's function4–12.
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BOROWSKI, E., CYBULSKA, B. Potassiumless Death of Saccharomyces cerevisiae Cells treated with N-Succinyl Perimycin and the Reversal of Fungicidal Action of the Antibiotic by Potassium Ions. Nature 213, 1034–1035 (1967). https://doi.org/10.1038/2131034a0
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DOI: https://doi.org/10.1038/2131034a0
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