Abstract
THE origin of the amniotic fluid proteins is at present a source of controversy. Existing information about these proteins, which has been derived mainly from paper electrophoresis1–6, immunoelectrophoresis7,8 and immuno-diffusion9, has divided investigators into those who believe that the amniotic fluid proteins arise from foetal serum and those who consider that their origin is maternal. A recent article10 has shown, by a combination of acrylamide disc electrophoresis and immuiiodiffusion, that the proteins of the amniotic fluid originate at least partly from maternal serum. It was found that haptoglobin 1–1 was present in all amniotic fluids derived from mothers of this type, while it was absent in the corresponding cord sera. Immunoglobulin A was also present only in amniotic fluids and corresponding maternal sera and absent in cord sera. In addition, transferrin and ceruloplasmin values approximated those of the maternal rather than those of foetal sera.
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An erratum to this article is available at https://doi.org/10.1038/213119c0
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USATEGUI-GOMEZ, M., MORGAN, D. Maternal Origin of the Group Specific (Gc) Proteins in Amniotic Fluid. Nature 212, 1600–1601 (1966). https://doi.org/10.1038/2121600a0
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DOI: https://doi.org/10.1038/2121600a0
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