Abstract
A NUMBER of immunological assay methods for human chorionic gonadotrophin (HCG) have been described recently. These include hæmagglutination1, latex particle agglutination2, and complement fixation3. These methods have been devised principally to detect or confirm pregnancy, and qualitative tests are usually adequate for this purpose. Patients with untreated choriocarcinoma excrete HCG in the urine. During the treatment of these patients with anti-metabolite drugs the concentration of HCG in the body fluids, which provides an index of the tumour's behaviour, falls rapidly to low levels. In these circumstances an assay method which is both more precise and more sensitive is needed. With this objective a radioimmunoassay technique, similar to that described by Hales and Randle for insulin4, has been applied to HCG.
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References
Wide, L., and Gemzell, C. A., Acta Endocrinol., 35, 261 (1960).
Henry, J. B., and Little, W. A., J. Amer. Med. Assoc., 182, 230 (1962).
Brody, S., and Carlstrom, G., Scand. J. Clin. and Lab. Invest., 13, 683 (1961).
Hales, C. N., and Randle, P. J., Biochem. J., 88, 137 (1963).
Greenwood, F. C., Hunter, W. M., and Glover, J. S., Biochem. J., 89, 114 (1963).
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WILDE, C., ORR, A. & BAGSHAWE, K. A Radioimmunoassay for Human Chorionic Gonadotrophin. Nature 205, 191–192 (1965). https://doi.org/10.1038/205191a0
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DOI: https://doi.org/10.1038/205191a0
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