Abstract
IN a previous paper1 we have shown that tyramine releases catecholamines but not ATP from isolated medullary granules, and that the released catecholamines are almost quantitatively replaced by the uptake of equimolar amounts of tyramine. Segontin [N-(3′-phenylpropyl-(2′))-1,1-diphenylpropyl-(3)-amine], a potent, dilator of the coronaries, causes, in vitro as well as in vivo, a release of catecholamines from the medullary granules2. In order to determine whether segontin acts like tyramine by displacing catecholamines from their binding sites we investigated the release of catecholamines and ATP by segontin and its uptake into the chromaffin granules. For comparison, experiments with reserpine were undertaken, as it is known that this compound also releases catecholamines from medullary granules in vivo and in vitro3,4.
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PHILIPPU, A., PALM, D. & SCHÜMANN, H. Effect of Segontin and Reserpine on Isolated Medullary Granules. Nature 205, 183 (1965). https://doi.org/10.1038/205183a0
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DOI: https://doi.org/10.1038/205183a0
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