Abstract
THE behaviour of dermal collagen fibrils in seleroderma has not often been investigated in ultra-thin skin sections1,2. In our investigations definite pathological alterations of the fine structure of collagen fibrils (axial periodicity, cross-band pattern, internal structure) were not detected either in circumscribed or in progressive scleroderma. As in normal dermis13, an antiparallel arrangement of adjacent fibrils in collagen fibres was found in both types of scleroderma. However, we were led to assume that the quantitative proportion of the two fibril types (R- and L-type) was not approximately 1 : 1 as in normal skin, but changed with a prevaluation of one of the two types.
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BRAUN-FALCO, O., RUPEC, M. Collagen Fibrils of the Scleroderma in Ultra-thin Skin Sections. Nature 202, 708–709 (1964). https://doi.org/10.1038/202708a0
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DOI: https://doi.org/10.1038/202708a0
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