Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Action of Prostaglandin E1 on Tissues which respond to Bradykinin

Nature volume 200, pages 892–893 (1963)Cite this article

Abstract

PROSTAGLANDIN E1 (9-keto, 11α, 15, dihydroxy-prost-13-enoic acid, PGE1) was the first of several prostaglandins to be isolated by Bergström et al.1,2. It is a member of a chemically new group of vasodilator substances. Other naturally occurring vasodilators such as bradykinin, acetylcholine and histamine have effects on several types of tissue in addition to smooth muscle. For example, bradykinin increases capillary permeability, produces pain on application to a blister base and releases adrenaline from the adrenal medulla3,4. The actions of PGE1 on these and other biological preparations have been investigated using bradykinin as a standard for comparison. The results are summarized in Table 1.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Bergström, S., and Sjoväll, J., Acta Chem. Scand., 14, 1701 (1960).

    Article  Google Scholar 

  2. Bergström, S., and Samuelsson, B., J. Biol. Chem., 237, 3005 (1962).

    PubMed  Google Scholar 

  3. Elliott, D. F., Horton, E. W., and Lewis, G. P., J. Physiol. (Lond.), 153, 473 (1960).

    Article  CAS  Google Scholar 

  4. Feldberg, W., and Lewis, G. P., J. Physiol. (Lond.), 167, 46, P (1963).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Miles-Ames Research Laboratories, Stoke Poges, Buckinghamshire

    E. W. HORTON

Authors
  1. E. W. HORTON
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

HORTON, E. Action of Prostaglandin E1 on Tissues which respond to Bradykinin. Nature 200, 892–893 (1963). https://doi.org/10.1038/200892b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/200892b0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing