Abstract
IN order to utilize radiotracers effectively, in an examination of bone cells, it became desirable to determine if the mitotic event was subject to the same diurnal changes observed for many other tissues1. The young proliferating cartilage epiphyseal plate served as a model since: (a) the zones in which mitotic activity occur are well defined; (b) the tissue homogeneity obviates problems of cell identification which obtain in metaphyseal bone. Two ‘spot-checks’ of serially independent groups of animals were made during a single 24-hr. period utilizing the colchicine method.
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SIMMONS, D. Diurnal Periodicity in Epiphyseal Growth Cartilage. Nature 195, 82–83 (1962). https://doi.org/10.1038/195082a0
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DOI: https://doi.org/10.1038/195082a0
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