Abstract
PLATELET life-span has been measured by incorporating into the platelet a tracer compound and following its disappearance. The labels used have included radioactive phosphorus, as 32P-orthophosphate and as 32P-diisopropyl fluorophosphonate, radioactive chromium, radioactive sulphur and radioactive carbon. Aas and Gardner1 reported a life-span of 9–11 days using in vitro labelling with chromium-51. Leeksma and Cohen2 calculated a life-span of 8–9 days using 32P-diisopropyl fluorophosphonate in vivo. Both methods gave a calculated life-span that was longer than previous results had suggested and longer than the 1½–3 day half-life for transfused 32P-platelets reported by Adelson et al. 3. These authors pointed out the hazards of using in vitro techniques and attempted to reduce platelet handling to a minimum. A longer platelet life-span would explain more adequately the occurrence of a maximum depression of platelets at 25–30 days in human beings exposed to radiation4.
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References
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GROSSMAN, C., MACEWAN, A. & DILLEY, J. The Half-life of Human Platelet Phosphatide. Nature 188, 950–951 (1960). https://doi.org/10.1038/188950a0
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DOI: https://doi.org/10.1038/188950a0
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