Abstract
CERTAIN influenza A viruses multiply readily in bovine kidney cells1. Calf kidney cells infected with the influenza A strain WS produce virus continuously for about 2 days and then cease to do so. Few cells degenerate. After a few more days influenza virus begins to appear again (Fig. 1). Periods in which the amount of virus formed rises and falls may alternate in this way for up to three months. Cultures, infected 6–12 days previously, which were yielding no detectable influenza virus hæmagglutinins, were found to be resistant to superinfection with Sendai virus. No hæmagglutinin was produced and no degeneration occurred.
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References
Heath, R. B., and Tyrrell, D. A. J., Arch.ges. Virusforsch, 8, 577 (1958).
Isaacs, A., and Lindenmann, J., Proc. Roy. Soc., B., 147, 258 (1957).
Burke, D. C., and Isaacs, A., Brit. J. Exp. Path., 39, 452 (1958).
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TYRRELL, D. Interferon produced by Cultures of Calf Kidney Cells. Nature 184, 452–453 (1959). https://doi.org/10.1038/184452a0
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DOI: https://doi.org/10.1038/184452a0
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