Abstract
TRYPTAMINE and its hydroxyl derivative are powerful radioprotective amines in vivo 1,2, but they also give rise to physiological changes. Bacq and Alexander3 state that tryptamine is not a vasoconstrictor, but is nevertheless as good a radiation protector of mice as 5-hydroxytryptamine. However, tryptamine causes intense smooth muscle contraction, similar to its hydroxyl derivative4,5. While this pharmacological activity for tryptamine is much less, molecule for molecule6, our studies indicate this also applies to its radioprotective properties in rats.
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References
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VAN DEN BRENK, H., ELLIOTT, K. Radioprotective Action of 5-Hydroxy-tryptamine. Nature 182, 1506–1507 (1958). https://doi.org/10.1038/1821506b0
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DOI: https://doi.org/10.1038/1821506b0
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