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Latent Infection of Rabbits by Adenovirus Type 5

Nature volume 180, pages 615–616 (1957)Cite this article

Abstract

ADENOVIRUSES were first isolated by Rowe, Huebner, Gilmore, Parrott and Ward1 from cultures of human adenoids undergoing spontaneous degeneration. The same group of workers2 observed that these agents can be isolated from a large proportion of adenoids and tonsils after these tissues are grown in vitro for a certain time. Attempts to isolate the virus by direct inoculation of tissue homo-genates into cultures of susceptible cells usually resulted in failure which was attributed to the presence of virus-neutralizing antibody demonstrated in these tissue homogenates. The process of ‘unmasking’ of the virus in tissue cultures would be a consequence of dilutions of this antibody as a result of successive fluid changes during tissue cultivation. Similar phenomena have been reported in the study of poliomyelitis3,4, salivary gland virus5, influenza6, psittacosis7 and typhus rickettsiæ8, and different mechanisms have been suggested to explain virus unmasking.

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References

  1. Rowe, W. P., Huebner, R. J., Gilmore, L. K., Parrott, R. H., and Ward, T. G., Proc. Soc. Exp. Biol. and Med., 84, 570 (1953).

    Article  CAS  Google Scholar 

  2. Rowe, W. P., Huebner, R. J., Hartley, J. W., Ward, T. G., and Parrott, R. H., Amer. J. Hyg., 61, 197 (1955).

    Google Scholar 

  3. Kaplan, A. S., Virology, 1, 377 (1955).

    Article  CAS  Google Scholar 

  4. Ackermann, W. W., and Kurtz, H., J. Exp. Med., 102, 555 (1955).

    Article  CAS  Google Scholar 

  5. Rowe, W. P., Hartley, J. W., Waterman, S., Turner, H. C., and Huebner, R. J., Proc. Soc. Exp. Biol. and Med., 92, 418 (1956).

    Article  CAS  Google Scholar 

  6. Price, W. H., Pub. Health Rep., 71, 125 (1956).

    Article  CAS  Google Scholar 

  7. Morgan, H. R., J. Exp. Med., 103, 37 (1956).

    Article  CAS  Google Scholar 

  8. Price, W. H., J. Bacterial., 69, 106 (1955).

    CAS  Google Scholar 

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Author notes

  1. H. G. PEREIRA

    Present address: National Institute for Medical Research, Mill Hill, London, N.W.7

Authors and Affiliations

  1. Common Cold Research Unit, Harvard Hospital, Salisbury, Wilts.

    H. G. PEREIRA & BARBARA KELLY

Authors
  1. H. G. PEREIRA
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  2. BARBARA KELLY
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PEREIRA, H., KELLY, B. Latent Infection of Rabbits by Adenovirus Type 5. Nature 180, 615–616 (1957). https://doi.org/10.1038/180615b0

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