Abstract
WE have recently described the effect of 5-hydroxy-tryptamine on acid gastric secretion elicited by histamine in dogs1. Recent experiments with its precursor 5-hydroxytryptophan have shown that this substance is also capable of inhibiting acid secretion. A technique has been used for recording the secretory-rate from a gastric cannula in anæsthetized dogs, as drops per min. on a kymograph. The acid output is expressed as mille equivalents, and is fairly constant after 1 hr. during histamine administered by continuous infusion (Table 1,a).
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References
Proceedings of International Symposium on HT, London, April 1957 (to be published by Pergamon Press).
Dalgliesh, C. E., and Dutton, R. W., Biochem. J., 65, 21 P (1957).
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SMITH, A., BLACK, J. & FISHER, E. Inhibitory Effect of 5-Hydroxytryptophan on Acid Gastric Secretion. Nature 180, 1127 (1957). https://doi.org/10.1038/1801127a0
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DOI: https://doi.org/10.1038/1801127a0
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