Abstract
MANY workers have found that the multiplication of viruses occurs in definite cycles, each involving several stages, namely, adsorption and entry to host cell, a loss of part or all of the infectivity, a ‘lag’ phase during which no new infective virus can be demonstrated, a period of intracellular rise in infectivity, and finally release of this virus followed by invasion of a fresh population of susceptible cells. We have studied the intracellular multiplication of ectromelia virus in mouse liver, using intravenous inoculation and assaying the infective titre of the liver at intervals. We have found that over a range of inocula from 106 to 1010 LD50 about 30 per cent of the inoculum is adsorbed to the liver in five minutes. Inocula of 109 LD50 infect practically all the liver cells within five minutes, as measured by a histological method1.
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de Burgh, P. M., Aust. J. Exp. Biol. Med. Sci., 28, 213 (1950).
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NOSSAL, G., DE BURGH, P. Growth Cycle of Ectromelia Virus in Mouse Liver. Nature 172, 671 (1953). https://doi.org/10.1038/172671a0
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DOI: https://doi.org/10.1038/172671a0
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