Abstract
IT has long been felt by several workers that adiposity is connected with the onset of diabetes mellitus. It has previously been reported by us1 that the intermediary fat metabolites such as ß-hydroxy butyric acid, aceto-acetic acid and pyruvic acid, when injected into normal rabbits in the form of their sodium salts, give rise to the condition of hyperglycæmia characterized by decreased sugar tolerance in those animals. It has also been observed by us2 that these substances can reduce the potency of external insulin while allowed to combine with them both in vitro as well as in vivo.
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NATH, M., BRAHMACHARI, H. Relation of Intermediary Metabolites to the Lowering of the Potency of Pancreatic Insulin in the Animal System. Nature 161, 18–19 (1948). https://doi.org/10.1038/161018c0
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DOI: https://doi.org/10.1038/161018c0
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