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Bile Production in Tumour-Bearing Mice and the Use of Bile in Filtration

Abstract

THE growth of a mouse sarcoma (Mal. sarcoma) produced originally by a derivative of 1: 2: 5: 6-dibenzanthracene1 when inoculated into the peritoneum of mice, is accompanied by various changes which resemble those produced by X-radiation2. Among these changes is a marked increase in bile secretion. This suggested the use of such bile: (a) in filtration experiments, as an addition to the material to be filtered, and (b) as a preliminary injection in order to damage the tissues at the site of a subsequent inoculation of filtrate.

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References

  1. Cook, J. W., J. Chem. Soc., 3277 (1931).

  2. Clarkson, J. R., Mayneord, W. V. and Parsons, L. D., J. Path. and Bact., 46, 221 (1938).

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  3. Parsons, L. P., J. Path. and Bact., 43, 1 (1936).

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PARSONS, L. Bile Production in Tumour-Bearing Mice and the Use of Bile in Filtration. Nature 144, 75–76 (1939). https://doi.org/10.1038/144075a0

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