This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
In-depth insights into Alzheimer’s disease by using explainable machine learning approach
Scientific Reports Open Access 20 April 2022
-
Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci
Scientific Reports Open Access 27 December 2018
-
Common genetic variation of the APOE gene and personality
BMC Neuroscience Open Access 20 May 2014
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Roses, A.D. Am. J. Med. Genet. 81, 49–57 ( 1998).
Saunders, A.M. et al. Neurology 43, 1467–1472 (1993).
Teng, E.L. & Chui, H.C. J. Clin. Psychiatry 48 , 314–318 (1987).
Jorm, A.F. & Jacomb, P.A. Psychol. Med. 19, 1015–1022 (1989).
Silverman, J.M., Breitner, J.C.S., Mohs, R.C. & Davis, K.L. Am. J. Psychiatry 143, 1279–1282 (1986).
Breitner, J.C.S. et al. Arch. Neurol. 52, 763–771 (1995).
McKhann, G. et al. Neurology 34, 939–944 ( 1984).
Kaplan, B.L. & Meier, P. J.A.S.A. 53, 457–481 (1958).
Norton, M.C., Breitner, J.C.S., Welsh, K.A. & Wyse, B.W. J. Am. Geriatr. Soc. 42, 1252–1256 ( 1994).
Morris, J.C. et al. Neurology 46, 707–719 ( 1996).
Acknowledgements
We thank the Neurogenetics Laboratory of the Bryan Alzheimer Disease Research Center at Duke University for determining the APOE genotypes from buccal material. J. Anthony and R. Brookmeyer provided helpful discussions on methods. We thank G. Einstein for her helpful critique of the manuscript.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Meyer, M., Tschanz, J., Norton, M. et al. APOE genotype predicts when — not whether — one is predisposed to develop Alzheimer disease. Nat Genet 19, 321–322 (1998). https://doi.org/10.1038/1206
Issue Date:
DOI: https://doi.org/10.1038/1206
This article is cited by
-
In-depth insights into Alzheimer’s disease by using explainable machine learning approach
Scientific Reports (2022)
-
Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci
Scientific Reports (2018)
-
Neuropathologically mixed Alzheimer’s and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes
Acta Neuropathologica (2015)
-
Genetic variants conferring susceptibility to Alzheimer’s disease in the general population; do they also predispose to dementia in Down’s syndrome
BMC Research Notes (2014)
-
Common genetic variation of the APOE gene and personality
BMC Neuroscience (2014)