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Hepatitis C virus infection in Lebanese patients with B-cell non-Hodgkin's lymphoma

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Abstract

Several studies from many countries have reported a high prevalence (>9%) of hepatitis C virus (HCV) infection in patients with B-cell non-Hodgkin lymphoma (B-NHL) suggesting a possible etiological role of HCV in the development of B-NHL. Data from the United Kingdom and Turkey, however, did not confirm these observations. To determine the prevalence of HCV infection in patients with B-cell lymphoma in Lebanon, a controlled study was conducted in which 318 Lebanese patients were investigated. These included 35 patients with B-NHL, 63 patients with various malignant conditions (control group 1) and 220 patients with non-malignant conditions (control group 2). Samples were tested in duplicates for antibodies to HCV (anti-HCV) by enzyme-linked immunosorbant assay (ELISA). None of the 318 patients investigated were anti-HCV positive. Based on our findings, it can be concluded, that, there is no sufficient evidence to indicate that HCV plays role in the development of B-NHL in Lebanese patients. Predisposing factors in lymphoproliferative disorders are numerous including both genetic and environmental factors that could vary from one geographic region to another.

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Authors and Affiliations

  1. Department of Internal Medicine, American University of Beirut, Beirut, Lebanon

    Z. Salem

  2. Department of Human Morphology, Faculty of Medicine, University of Beirut, Beirut, Lebanon

    N. Nuwaiyri-Salti

  3. Department of Medical Laboratory Technology, Faculty of Health Sciences, American University of Beirut, Beirut, Lebanon

    F. Ramlawi & S. Ramia

Authors
  1. Z. Salem
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  2. N. Nuwaiyri-Salti
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  3. F. Ramlawi
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  4. S. Ramia
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Salem, Z., Nuwaiyri-Salti, N., Ramlawi, F. et al. Hepatitis C virus infection in Lebanese patients with B-cell non-Hodgkin's lymphoma. Eur J Epidemiol 18, 251–253 (2003). https://doi.org/10.1023/A:1023380316098

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