Abstract
Nitrates are old drugs, available in many formulations, that are effective in relieving symptoms in various CAD syndromes as well as congestive heart failure. Nitrate tolerance is the major problem limiting nitrate efficacy and use by physicians. Currently, an intermittent dosing strategy is the only practical way to limit the development of tolerance or attenuation of nitrate actions.
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References
Goldstein I, Padma-Nathan H, et al. Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med 1998;338:1397–1404.
Rendell MS, Rajfer J, Wicker PA, Smith MD. Sildenafil for treatment of erectile dysfunction in men with diabetes: A randomized controlled trial. JAMA 1999;281:421–426.
Abrams J, Elkayam U, Thadani U, et al. Tolerance: An historical overview. Am J Cardiol 1998;81:3A–14A.
Parker JD, Parker JO. Nitrate therapy for stable angina pectoris. N Engl J Med 1998;338:520–531.
Thadani U. Nitrate tolerance, rebound, and their clinical relevance in stable angina pectoris, unstable angina and heart failure. Cardiovasc Drug Ther 1996;10:735–742.
DeMots H, Glasser SP. Intermittent transdermal nitroglycerin therapy in the treatment of chronic stable angina. J Am Coll Cardiol 1989;13:786–788.
Webb DJ, Muirhead GJ, Wulff M, et al. Sildenafil citrate potentiates the hypotensive effects of nitric oxide donor drugs in male patients with stable angina. J Am Coll Cardiol 2000;36:25–31.
Zusman RM. Cardiovascular data on sildenafil citrate. Am J Cardiol 1999;83 (5A):1C–44C.
Cheitlin MD, Hutter AM, Brindis RG, et al. Use of Sildanefil (Viagra) in patients with cardiovascular disease. American College of Cardiology-American Heart Association Expert Consensus Document. JAmer Coll Cardiol 1999;33:273–282. Review.
Kanamasu K, Takenika T, Hayashi T, et al. Increased incidence of cardiac events in post-myocardial infarction patients treated with long-term oral isosorbide dinitrate. Circulation 1998;98 (Suppl):I637(Abstract).
Nakamura Y, Moss AJ, Brown MW, et al. Long-term nitrate use may be deleterious in ischemic heart disease: A study using the databases from two large-scale post-infarction studies. Multicenter Myocardial Ischemia Research Group. Am Heart J 1999;138:577–585.
Judgutt BI. Nitrates in myocardial infarction, in nitrates updated: Current use in angina, ischemia, infarction and heart failure. In: Thadani U, Opie LH, eds. Boston: Kluwer Academic Publisher, 1995:150–174.
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Abrams, J. How to Use Nitrates. Cardiovasc Drugs Ther 16, 511–514 (2002). https://doi.org/10.1023/A:1022982213484
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DOI: https://doi.org/10.1023/A:1022982213484