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Cytogenetic Aberrations in the Cells of Liver and Spermatogenic Epithelium in Senescence Accelerated SAMP1 and SAMR1 Mice

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Abstract

It was shown that during ontogenesis, the mice prone to (SAMP1) and resistant (SAMR1) against accelerates senescence did not differ substantially in the frequency of cytogenetic aberrations in the hepatocytes and spermatogenic cells (spermatogonia and round spermatids). These data suggest that in the mice of both lines, the processes of appearance, development, and functioning of complex biological systems, such as liver and spermatogonic epithelium take place against the background of high genetic instability. The role of genetic instability in senescence is discussed.

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Authors and Affiliations

  1. Biological Faculty and Institute of Mechanics, Moscow State University, Vorob'evy gory, Moscow, 119899, Russia

    S. T. Zakhidov, A. V. Gopko, M. L. Semenova, Ya. Yu. Mikhaleva & A. A. Makarov

  2. Russian Academy of Sciences, Kol'tsov Institute of Developmental Biology, ul. Vavilova 26, Moscow, 119991, Russia

    T. L. Marshak, I. V. Uryvaeva & G. V. Delone

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  1. S. T. Zakhidov
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  2. T. L. Marshak
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  3. I. V. Uryvaeva
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Zakhidov, S.T., Marshak, T.L., Uryvaeva, I.V. et al. Cytogenetic Aberrations in the Cells of Liver and Spermatogenic Epithelium in Senescence Accelerated SAMP1 and SAMR1 Mice. Russian Journal of Developmental Biology 33, 362–373 (2002). https://doi.org/10.1023/A:1021158727040

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