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Serum Interleukin-10 in Human Acute Pancreatitis

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Abstract

Interleukin 10 (IL-10) recently emerged as anantiinflammatory cytokine that inhibits the secretion ofproinflammatory cytokines by monocytes and/ormacrophages and the release of free oxygen radicals. It has been reported that treatment with IL-10decreases the severity of experimental pancreatitis,mainly by inhibiting cellular necrosis. The aim of thisstudy was to evaluate the behavior of serum IL-10 in patients with acute pancreatitis and toexplore the possibility of a relationship between thiscytokine and severity of the disease. Forty-fivepatients with acute pancreatitis were studied. Acutepancreatitis was of biliary origin in 30 patients, due toalcohol abuse in 10, due to pancreas divisum in 1, andof unknown origin in the remaining 4. According to theBalthazar criteria, 19 patients had scores of A, B, or C and 25 had scores of D or E. Twelvehealthy subjects were also studied as controls. SerumIL-10 was determined in all subjects on admission, andin acute pancreatitis patients also daily for the following four days using a commercial kit.Healthy subjects had no detectable serum levels ofIL-10. In acute pancreatitis patients, serum IL-10levels were increased on the first day of the diseaseand then progressively decrease in the followingdays. On the first day of the acute pancreatitis,patients with the mild disease had serum levels of IL-10significantly higher than those with severe disease, whereas in the following days, no statisticallysignificant difference was observed between the twogroups. The elevation of IL-10 on the first day of theillness is more marked in patients with mild acute pancreatitis than in those with the severe formof the disease. The finding of low values of serum IL-10in severe acute pancreatitis suggests that there may bealtered down-regulation of the immune system response in these patients.

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Authors
  1. Raffaele Pezzilli
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  2. Paola Billi
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  3. Rita Miniero
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  4. Bahjat Barakat
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Pezzilli, R., Billi, P., Miniero, R. et al. Serum Interleukin-10 in Human Acute Pancreatitis. Dig Dis Sci 42, 1469–1472 (1997). https://doi.org/10.1023/A:1018814710291

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