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Role of Activation of the Sympathoadrenal System in the Realization of Immune Reactions during Acute Poisoning with Organophosphorus Compounds

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Abstract

Experiments on Wistar rats showed that acute poisoning with organophosphorus compound dimethyldichlorovinylphosphate (0.2 and 0.8 LD50) was accompanied by suppression of the major immune reactions. Increasing the concentration of epinephrine and norepinephrine in the plasma produced less pronounced opposite effects, except for the influence on natural killer activity.

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Authors and Affiliations

  1. Saratov State Medical University, Russia

    P. F. Zabrodskii & V. G. Germanchuk

  2. Saratov Military Institute of Radiation, Chemical, and Biological Protection, Russia

    P. F. Zabrodskii & V. G. Germanchuk

Authors
  1. P. F. Zabrodskii
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  2. V. G. Germanchuk
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Zabrodskii, P.F., Germanchuk, V.G. Role of Activation of the Sympathoadrenal System in the Realization of Immune Reactions during Acute Poisoning with Organophosphorus Compounds. Bulletin of Experimental Biology and Medicine 132, 966–968 (2001). https://doi.org/10.1023/A:1013667227881

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  • DOI: https://doi.org/10.1023/A:1013667227881

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