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Inhibition of Bovine Carbonic Anhydrase by New Sulfonamide Compounds

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Abstract

Inhibitory effects of three new derivatives of 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide on bovine carbonic anhydrase have been investigated. The new compounds are 2-(3-chloropropionylamino)-1,3,4-thiadiazole-5-sulfonamide, 2-(2,2-dichloroacetylamino)-1,3,4-thiadiazole-5-sulfonamide, and 2-(3-phenylpropionylamino)-1,3,4-thiadiazole-5-sulfonamide. The new compounds inhibit the esterase activity of carbonic anhydrase noncompetitively and have inhibition constants and I 50 values very similar to those for 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide, the latter being clinically used in the treatment of glaucoma.

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  1. Department of Chemistry, Balikesir University Faculty of Science and Arts, Balikesir, Turkey

    O. Arslan

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  1. O. Arslan
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Arslan, O. Inhibition of Bovine Carbonic Anhydrase by New Sulfonamide Compounds. Biochemistry (Moscow) 66, 982–983 (2001). https://doi.org/10.1023/A:1012365424900

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