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Tumor-Induced Osteomalacia

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References

  1. Park EA. Observations on the pathology of rickets with particular reference to the changes at the cartilage-shaft junctions of the growing bones. Bull NY Acad Med 1939;15:495-543.

    Google Scholar 

  2. Baylink D, Stauffer M, Wegedal J, Rich C. Formation, mineralization and resorption of bone in vitamin D-deficient rats. J Clin Invest 1970;49:1122-1134.

    Google Scholar 

  3. McCance RA. Osteomalacia with looser's nodes (milkman's syndrome) due to a raised resistance to vitamin D acquired about the age of 15 years. Quart J Med 1947;16:33-46.

    Google Scholar 

  4. Prader AV, Illig R, Uehilinger E, Stalder G. Rachitis infolge knochentumors. Helvetica Paediat Acta 1959;14:554-565.

    Google Scholar 

  5. Hauge BM. Vitamin D resistant osteomalacia. Acta Med Scandinavica 1956;153:271-282.

    Google Scholar 

  6. Yoshikawa S, Kawabata M, Hatsuyama Y, Hosokawa O, Fujita T. A typical vitamin-D resistant osteomalacia. Report of a Case. J Bone Joint Surg 1964;45-A:998-1007.

    Google Scholar 

  7. Krane SM. Case records of the massachusetts general hospital. New England J Med 1965;273:1330.

    Google Scholar 

  8. Salassa RM, Jowsey J, Arnaud CD. Hypophosphatemic osteomalacia induced with “nonendocrine” tumors. New England J Med 1970;283:65-70.

    Google Scholar 

  9. Evans DJ, Azzopardi JG. Distinctive tumors of bone and soft tissue causing acquired vitamin-D-resistant osteomalacia. Lancet 1972;1:353-354.

    Google Scholar 

  10. Olefsky J, Kempson R, Jones H, Reaven G. “Tertiary” hyperparathyroidism and apparent “cure” of vitamin-D-resistant rickets after removal of an ossifying mesenchymal tumor of the pharynx. New England J Med 1972;286:740-745.

    Google Scholar 

  11. Pollack JA, Schiller AL, Crawford JD. Rickets and myopathy cured by removal of a nonossifying fibroma of bone. Pediatrics 1973;52:364-371.

    Google Scholar 

  12. Moser CR, Fessel WJ. Rheumatic manifestations of hypophosphatemia. Arch Intern Med 1974;134:674-678.

    Google Scholar 

  13. Willhoite DR. Acquired rickets and solitary bone tumor. The question of a causal relationship [abstract]. Clin Orthop 1975;109:210-211.

    Google Scholar 

  14. Linovitz RJ, Resnick D, Keissling P, Kondon JJ, Sehler B, Nejdl RJ, Rowe JH, Deftos LJ. Tumor-induced osteomalacia and rickets: a surgically curable syndrome. Report of two cases. J Bone Joint Surg 1976;58-A:419-423.

    Google Scholar 

  15. Renton P, Shaw DG. Hypophosphatemic osteomalacia secondary to vascular tumors of bone and soft tissue. Skel Radiol 1975;1:21-24.

    Google Scholar 

  16. Morita M. A case of adult onset vitamin D-resistant osteomalacia induced with soft tissue tumor. Kotsu Taisha (Bone metabolism) 1976;9:286-291.

    Google Scholar 

  17. Aschinberg LC, Soloman LM, Zeis PM, Justice P, Rosenthal IM. Vitamin D-resistant rickets induced with epidermal nevus syndrome: demonstration of a phosphaturic substance in the dermal lesions. J Pediat 1977;91:56-60.

    Google Scholar 

  18. Drezner MK, Feinglos MN. Osteomalacia due to 1,25-dihydroxycholecalciferol deficiency. Association with a giant cell tumor of bone. J Clin Invest 1977;60:1046-1053.

    Google Scholar 

  19. Yoshikawa S, Nakamura T, Takagi M, Imamura T, Okano K, Sasaki S. Benign osteoblastoma as a cause of osteomalacia. A report of two cases. J Bone Joint Surg 1977;59-B[3]:279-289.

    Google Scholar 

  20. Wyman AL, Paradinas FJ, Daly JR. Hypophosphataemic osteomalacia induced with a malignant tumor of the tibia: report of a case. J Clin Pathol 1977;30:328-335.

    Google Scholar 

  21. Leite MOR, Borelli A, de Ulhoa Cintra AB. Osteomalacia hipofosfatemica associada a hemangio-fibroma. Consideracoes etiopaogenicas. Rev Hosp Clin Fac Med San Paulo 1978;33:65-67.

    Google Scholar 

  22. Lau K, Strom MC, Goldberg M, Goldfarb S, Gray RW, Lemann R, Jr. Agus ZS. Evidence for a humoral phosphaturic factor in oncogenic hypophosphatemic osteomalacia [abstract]. Clin Res 1979;27:421A.

    Google Scholar 

  23. Wener M, Cohen L, Bar RS, Strottmann MP, DeLuca H. Regulation of phosphate and calcium metabolism by vitamin D metabolites: studies in a patient with oncogenic osteomalacia [abstract]. Arthrit and Rheumat 1979;22:672-673.

    Google Scholar 

  24. Turner ML, Dalinka MK. Osteomalacia: Uncommon causes. Am J Roentgenol 1979;133:539-540.

    Google Scholar 

  25. Nortman DF, Coburn JW, Brautbar N, Sherrard DJ, Haussler MR, Singer FR, Brickman AS, Barton RT. Treatment of mesenchymal tumor induced osteomalacia (MTAO) with 1,25(OH)2D3. Report of a case. In: Norman AW, ed. Vitamin D, Basic Research and its Clinical Application. Proceedings of the Fourth Workshop on Vitamin D. Berlin: De Gruyter, 1979;1167-168.

    Google Scholar 

  26. Daniels RA, Weisenfeld I. Tumorous phosphaturic osteomalacia. Report of a case induced with multiple hemangiomas of bone. Am J Med 1979;67:155-159.

    Google Scholar 

  27. Fukumoto Y, Tarui S, Tsukiyama K, Ichihara K, Moriwaki K, Nonaka K, Mizushima T, Kobayashi Y, Dokoh S, Fukunaga M, Morita R. Tumor-induced vitamin D-resistant hypophosphatemic osteomalacia induced with proximal renal tubular dysfunction and 1,25-dihydroxyvitamin D deficiency. J Clin Endocrinol Metab 1979;49:873-878.

    Google Scholar 

  28. Lejeune E, Bouvier M, Meunier P, Vauzelle JL, Deplante JP, David L, Llorca G, Andre-Fouet E. L'osteomalacie des tumeurs mesenchymateuses. A propos d'une noouvelle observation. Rev Rhumat 1979;46:187-193.

    Google Scholar 

  29. Crouzet J, Camus JP, Gatti JM, Descamps H, Beraneck L. Osteomalacie hypophosphoremique et hemangiopericytome de la voute du crane. Rev Rhumat 1980;47:523-528.

    Google Scholar 

  30. Camus JP, Courzet J, Prier A, Guillemant S, Ulmann A, Koeger AC. Osteomalacies hypophosphoremiques gueries par l'ablation de tumeurs benignes du tissu conjonctif: etude de trois observations avec dosages pre-et post-operatoires des metabolites de la vitamine D. Ann Med Interne 1980;131:422-426.

    Google Scholar 

  31. Sweet RA, Males JL, Hamstra AJ, Deluca HF. Vitamin D metabolite levels in oncogenic osteomalacia. Ann Intern Med 1980;93:279-280.

    Google Scholar 

  32. Lyles KW, Berry WR, Haussler M, Harrelson JM, Drezner MK. Hypophosphatemic osteomalacia: association with prostatic carcinoma. Ann Intern Med 1980;93:275-278.

    Google Scholar 

  33. Nitzan DW, Marmary Y, Azaz B. Mandibular tumor-induced muscular weakness and osteomalacia. Oral Surg Oral Med and Oral Pathol 1981;52:253-256.

    Google Scholar 

  34. Asnes RS, Berdon WE, Bassett CA. Hypophosphatemic rickets in an adolescent cured by excision of a nonossifying fibroma. Clin Pediat 1981;20:646-648.

    Google Scholar 

  35. Parker MS, Klein I, Haussler MR, Mintz DH. Tumor-induced osteomalacia. Evidence of a surgically correctable alteration in vitamin D metabolism. J Am Med Assn 1981;245:492-493.

    Google Scholar 

  36. Chacko V, Joseph B. Osteomalacia induced with hemiangiopericytoma. J Indian Med Assn 1981;76:173-175.

    Google Scholar 

  37. Hioco J, Chanzy MO, Hioco F, Voisin MC, Villiaumey J. Osteomalacia with mesenchymal tumors--two new cases [abstract]. Rev Rhumat Special 1981;890.

  38. Barcelo P, Jr. Asensi E, Paso M, Obach J, Barcelo P, Sr. Osteomalacia hipofosforemica secundaria as histiocitoma fibroso vascular [abstract]. Rev Rhumat Special 1981;1352.

  39. Nomura G, Koshino Y, Morimoto H, Kida H, Noura S, Tamai K. Vitamin D resistant hypophosphatemic osteomalacia induced with osteosarcoma of the mandible. Report of a case. Japanese J Med 1982;21:35-39.

    Google Scholar 

  40. Ryan EA, Reiss E. Oncogenous osteomalacia. Review of the world literature and report of two new cases. Am J Med 1984;77:501-512.

    Google Scholar 

  41. Firth RG, Grant CS, Riggs BL. Development of hypercalcemic hyperparathyroidism after long-term phosphate supplementation in hypophosphatemic osteomalacia. Report of two cases. Am J Med 1985;78:669-673.

    Google Scholar 

  42. Taylor HC, Fallon MD, Velasco ME. Oncogenic osteomalacia and inappropriate antidiuretic hormone secretion due to oat-cell carcinoma. Ann Int Med 1984;101:786-788.

    Google Scholar 

  43. Leehey DJ, Ing TS, Daugirdas JT. Fanconi syndrome induced with a non-ossifying fibroma of bone. Am J Med 1985;78:708-710.

    Google Scholar 

  44. Seshadri MS, Cornish CJ, Mason RS, Posen S. Parathyroid hormone-like bioactivity in tumors from patients with oncogenic osteomalacia. Clin Endocrinology 1985;23:689-697.

    Google Scholar 

  45. Cotton GE, Van Puffelen P. Hypophosphatemic osteomalacia secondary to neoplasia. J Bone Joint Surg 1986;68A:129-133.

    Google Scholar 

  46. Murphy P, Wright G, Rai GS. Hypophosphatemic osteomalacia induced with prostatic carcinoma. Br Med J 1985;290:1945.

    Google Scholar 

  47. Gitelis S, Ryan WG, Rosenberg AG, Templeton AC. Adult-onset hypophosphatemic osteomalacia secondary to neoplasm: a case report and review of the pathophysiology. J Bone Joint Surg 1986;68A:134-138.

    Google Scholar 

  48. Rico H, Fernandez-Miranda E, Sanz J, Gomez-Castresana F, Escriba A, Hernandez ER, Krsnik I. Oncogenous osteomalacia: a new case secondary to a malignant tumor. Bone 1986;7:325-329.

    Google Scholar 

  49. Carey DE, Drezner MK, Hamdan JA, Mange M, Ashmad MS, Mubarak S, Nyhan WL. Hypophosphatemic rickets/osteomalacia in linear sebaceous nevus syndrome: a variant of tumor-induced osteomalacia. J Pediatr 1986;109:994-1000.

    Google Scholar 

  50. Siris ES, Clemens TL, Dempster DW, Shane E, Segre GV, Lindsay R, Bilezekian JP. Tumor-induced osteomalacia: kinetics of calcium phosphorus and vitamin D metabolism and characteristics of bone histomorphometry. Am J Med 1987;82:307-312.

    Google Scholar 

  51. Reid IR, Teitelbaum SL, Dusso A, Whyte MP. Hypercalcemic hyperparathyroidism complicating oncogenic osteomalacia: effect of successful tumor resection on mineral homeostasis. Am J Med 1987;83:350-354.

    Google Scholar 

  52. Prowse M, Brooks PM. Oncogenic hypophosphatemic osteomalacia induced with a giant cell tumor of a tendon sheath. Aust NZ J Med 1987;17:330-332.

    Google Scholar 

  53. Sparagana M. Tumor-induced osteomalacia: long-term follow-up of two patients cured by removal of their tumors. J Surg Oncology 1987;36:198-205.

    Google Scholar 

  54. Rao DS, Parfitt AM, Villanueva AR, Dorman PJ, Kleerekoper M. Hypophosphatemic osteomalacia and adult fanconi syndrome due to light-chain nephropathy: another form of oncogenous osteomalacia. Am J Med 1987;82:333-338.

    Google Scholar 

  55. McClure J, Smith PS. Oncogenic osteomalacia. J Clin Pathol 1987;40:446-453.

    Google Scholar 

  56. Miyauchi A, Fukase M, Tsutsumi M, Fujita T. Hemangiopericytoma-induced osteomalacia: tumor transplantation in nude mice causes hypophosphatemia and tumor extracts inhibit renal 25-hydroxyvitamin D-1-hydroxylase activity. J Clin Endocrinol Metab 1988;67:46-53.

    Google Scholar 

  57. Konishi K, Nakamura M, Yamakawa H, Suzuki H, Saruta T, Hanaoka H, Davatchi T. Case report: hypophosphatemic osteomalacia in von recklinghausen neurofibromatosis. Am J Med Sciences 1991;301:322-328.

    Google Scholar 

  58. Nitzan DW, Horowitz AT, Darmon D, Friedlaender MM, Rubinger D, Stein P, Bab I, Popovtzer MM, Silver J. Oncogenous osteomalacia: a case study. Bone and Mineral 1989;6:191-197.

    Google Scholar 

  59. McGuire MH, Merenda JT, Etzkorn JR, Sundaram M. Oncogenic osteomalacia: a case report. Clin Orthop and Rel Res 1989;244:305-308.

    Google Scholar 

  60. Schultze G, Delling G, Faensen M, Haubold R, Loy V, Molzahn M, Pommer W, Semier J, Trempenau B. Onkogene hypophosphatamische osteomalazie. Kurze Originalien and Falberichte 1989;114:1073-1078.

    Google Scholar 

  61. Leicht E, Biro G, Langer H.-J. Tumor-induced osteomalacia: preand postoperative biochemical findings. Horm Metab Res 1990;22:640-643.

    Google Scholar 

  62. Uchida H, Yokoyama S, Kashima K, Nakayama I, Shimizu, Masumi S. Oncogenic vitamin D resistant hypophosphatemic osteomalacia (benign ossifying mesenchymal tumor of bone): Case report. Jpn J Clin Oncol 1991;21:218-226.

    Google Scholar 

  63. Papotti M, Foschini MP, Isia G, Rizzi G, Betts C, Eusebi V. Hypophosphatemic oncogenic osteomalacia: report of three new cases. Tumori 1988;74:599-607.

    Google Scholar 

  64. Dent CE, Stamp TCB. Vitamin D rickets and osteomalacia. In: Avioli LV, Krane S, eds. Metabolic Bone Disease, vol 1. New York: Academic Press, 1978;237.

    Google Scholar 

  65. Dent CE, Gertner JM. Hypophosphatemic osteomalacia in fibrous dysplasia. Q J Med 1976;45:411-420.

    Google Scholar 

  66. Saville PD, Nassim JR, Stevenson FH. Osteomalacia in von Recklinghausen's neurofibromatosis: Metabolic study of a case. Br Med J 1955;1:1311-1313.

    Google Scholar 

  67. Weidner N, Cruz DS. Phosphaturic mesenchymal tumors: a polymorphous group causing osteomalacia or rickets. Cancer 1987;59:1442-1454.

    Google Scholar 

  68. Boriani S, Campanacci. Osteoblastoma associated with osteomalacia ( presentation of a case and review of the literature). Ital J Orthop Traumatol 1978;4:379-382.

    Google Scholar 

  69. Castleman B, McNeely BU. Case records of the Massachusetts General Hospital: case 38-1965. N Engl J Med 1965;273:494-504.

    Google Scholar 

  70. Robertson A. Case of the winter season. Semin Roentgenol 1983;18:5-6.

    Google Scholar 

  71. Kabadi UM. Osteomalacia associated with prostatic cancer and osteoblastic metastases. Urology 1983;21:65-67.

    Google Scholar 

  72. Moncrieff MW, Brenton DP, Arthur LJH. Case of tumor rickets. Arch Dis Childhood 1978;53:740-745.

    Google Scholar 

  73. Cramer SF, Aikawa M, Cebelin M. Neurosecretory granules in small cell invasive carcinoma of the urinary bladder. Cancer 1981;47:724-730.

    Google Scholar 

  74. Ioakimidis DE, Dendrinos GK, Frangia KB, Babiolakis DN, Chilas GI, Lyberopoulos KL, Kontomerkos TK. Tumor induced osteomalacia. J Rheumatol 1994;21:1162-1164.

    Google Scholar 

  75. Lee HK, Sung WW, Dolodnik P, Shimshi M. Bone scan in tumorinduced osteomalacia. J Nucl Med 1995;36:247-249.

    Google Scholar 

  76. Harvey JN, Gray C, Belchetz PE. Oncogenous osteomalacia and malignancy. Clin Endocrinol 1992;37:379-384.

    Google Scholar 

  77. Cehreli C, Alakavuklar MN, Cavdar C, Basdemir G, Undar B, Akkoc N, Payzin B, Oztop F. Oncogenous osteomalacia--report of a case. Acta Oncologica 1994;33:975-980.

    Google Scholar 

  78. Schapira D, Izhak OB, Nachtigal A, Burstein A, Shalom RB, Shagrawi I, Best LA. Tumor-induced osteomalaica. Sem Arth Rheum 1995;25:35-46.

    Google Scholar 

  79. Shaker JL, Brickner RC, Divgi AB, Raff H, Findling JW. Case report: Renal phosphate wasting, syndrome of inappropriate antidiuretic hormone and ectopic corticotropin production in small cell carcinoma. Am J Med Sci 1995;310:38-41.

    Google Scholar 

  80. Yu GH, Katz RL, Raymond AK, Gagel RF, Allison A, McCutcheion I. Oncogenous osteomalacia: fine needle aspiration of a neoplasm with a unique endocrinologic presentation. Act Cytologica 1995;39:831-832.

    Google Scholar 

  81. Linsey M, Smith W, Yamauchi H, Bernstein L. Nasopharyngeal angiofibroma presenting as adult osteomalacia: Case report and review of the literature. Laryngoscope 1982;93:1328-1331.

    Google Scholar 

  82. Nuovo MA, Dorfman HD, Sun C-CJ, Chalew S. Tumor-induced osteomalacia and rickets. Am J Surg Pathol 1989;13:588-589.

    Google Scholar 

  83. Hernberg CA, Edgren W. Looser-Milkman's syndrome with neurofibromatosis Recklinghause and general decalcification of the skeleton. Acta Medica Scandinavica 1949;136:26-33.

    Google Scholar 

  84. Hosking DJ, Chamberlain MJ, Whortland-Webb WR. Osteomalacia and carcinoma of prostate with major redistribution of skeletal calcium. Br J Radiol 1975;48:451-456.

    Google Scholar 

  85. Weidner N, Bar RS, Weiss D, Strottmann MP. Neoplastic pathology of oncogenic osteomalacia/rickets. Cancer 1985;55:1691-1705.

    Google Scholar 

  86. Cai Q, Hodgson SF, Kao PC, Lennon VA, Klee GG, Zinsmiester AR, Kumar R. Brief report: Inhibition of renal phosphate transport by a tumor product in a patient with oncogenic osteomalacia. N Engl J Med 1994;330:1645-1649.

    Google Scholar 

  87. Kim YG, Choi YS, Lee SC, Ryu DM. Tumor-induced osteomalacia asociated with lesions in the oral and maxillofacial region: Report of two cases. J Oral Maxillofac Surg 1996;54:1352-1357.

    Google Scholar 

  88. David K, Revesz T, Kratimenos, Krausz T, Crockard HA. Oncogenic osteomalacia associated with a meningeal phosphaturic mesenchymal tumor. J Neurosurg 1996;84:288-292.

    Google Scholar 

  89. Wilkins GE, Granleese S, Hegele RG, Holden J, Anderson DW, Bondy GP. Oncogenic osteomalacia: Evidence for a humoral phosphaturic factor. J Clin Endocrinol Metab 1995;80:1628-1634.

    Google Scholar 

  90. Reese DM, Rosewn PJ. Oncogenic osteomalacia associated with prostate cancer. J Urol 1997;158:887.

    Google Scholar 

  91. Nakahama H, Nakanishi T, Uno H, Takaoka T, Taji N, Uyama O, Kitada O, Sugita M, Miyauchi A, Sugishita T, Fujita T. Prostate cancer-induced oncogenic hypophosphatemic osteomalacia. Urol Int 1995;55:38-40.

    Google Scholar 

  92. Ivker R, Resnick SD, Skidmore RA. Hypophosphatemic vitamin D-resistant rickets, precocious puberty and the epidermal nevus syndrome. Arch Dermatol 1997;133:1557-1561.

    Google Scholar 

  93. Ejima E, Kiriyama T, Fujiyama K, Abe Y, Ashizawa K, Tominaga T, Sera N, Tamura M, Yokoyama N, Nagataki S. Culture oncogenic osteomalacia tumor cells produce a factor(s) that inhibits osteocalcin production by osteoblastic cells. Oncology Reports 1997;4:1327-1330.

    Google Scholar 

  94. Shane E, Parisien M, Henderson JE, Dempster DW, Feldman F, Hardy MA, Tohme JF, Karaplis AC, Clemens TL. Tumor-induced osteomalacia: Clinical and basic studies. J Bone Min Res 1997;12:1502-1511.

    Google Scholar 

  95. Caille A, Crouzet J, Minoune H, Duterque M, Perrin P, Verola O. Ostéomalacie guérie par résection d'un neurinome cutané. Ann Dermatol Benereol 1996;123:829-831.

    Google Scholar 

  96. Rowe PSN, Ong ACM, Cockerill FJ, Goulding JN, Hewison M. Candidate 56 and 58kDA Protein(s) responsible for the mediating the renal defects in oncogenic hypophosphatemic osteomalacia. Bone 1996;18:159-169.

    Google Scholar 

  97. Gonzalez-Compta X, Manńós-Rujol M, Foglia-Fernandez M, Perol E, Condom E, Claveguera T, Dicenta-Sousa M. Oncogenic osteomalacia: Case report and review of head and neck associated tumors. J Laryngology & Otology 1998;112:389-392.

    Google Scholar 

  98. Nelson AE, Namkung HJ, Patava J, Wilinson MR, Chang AC-M, Reddel RR, Robinson BG, Mason RS. Characteristics of tumor cell bioactivity in oncogenic osteomalacia. Molecular and Cellular Endocrinology 1996;124:17-23.

    Google Scholar 

  99. Francçois S, Lefort G, Poli-Merol ML, Gaillard B, Roussel V, Sulmont SD. Rachitisme vitamino-résistant guéri par l'éxérése d'une tumeur osseuse. Revue de chirurgie orthopédique 1997;83:387-392.

    Google Scholar 

  100. Marie PJ, Glorieux FH. Bone histomorphometry in asymptomatic adults with hereditary hypophosphatemic vitamin D-resistant osteomalacia. Metab Bone Dis Relat Res 1982;4:249-253.

    Google Scholar 

  101. Lyles KW, Burkes EJ, Jr. McNamara CR, Harrelson JM, Pickett JP, Drezner MK. The concurrence of hypoparathyroidism provides new insights to the pathophysiology of X-linked hypophosphatemic rickets. J Clin Endocrinol Metab 1985;60:711-717.

    Google Scholar 

  102. Drezner MK, Lyles KW, Harrelson JM. Vitamin D resistant osteomalacia: Evaluation of vitamin D metabolism and response to therapy. In: Choh DV, Talmage RV, Matthews JL. eds. Hormonal Control of Calcium Metabolism. Amsterdam: Excerpta Medica, 1980;243-251.

    Google Scholar 

  103. Lyles KW, Harrelson JM, Drezner MK. The efficacy of vitamin D2 and oral phosphorus therapy in X-linked hypophosphatemic rickets and osteomalacia. J Clin Endocrinol Metab 1982;54:307-315.

    Google Scholar 

  104. Drezner MK, Lyles KW, Haussler MR, Harrelson JM. Evaluation of a role for 1,25-dihydroxyvitamin D3 in the pathogenesis and treatment of X-linked hypophosphatemic rickets and osteomalacia. J Clin Invest 1980;66:1020-1032.

    Google Scholar 

  105. Miller MJ, Marel G, Frame B. Adult acquired vitamin D and PTHresistant hypophosphatemic osteomalacia with multiple skeletal lesions. In Norman AW, Schaefer K, Herrah DV, Grigoleit HG, eds. Vitamin D-Chemical, Biochemical and Clinical Endocrinology of Calcium Metabolism. New York: de Gruyter, 1982;993-995.

    Google Scholar 

  106. Saggese G, Baronceli GI, Berteloni S, Perri G. Long-term growth hormone treatment in children with renal hypophosphatemic rickets: Effects on growth, mineral metabolism and bone density. J Pediatr 1995;127:395-402.

    Google Scholar 

  107. Agus ZS. Renal handling of phosphate. In: Massry SG, Glassock RJ, eds. Textbook of Nephrology. Baltimore: Williams & Wilkins, 1983:389.

    Google Scholar 

  108. Cheng L, Jacktor B. Sodium gradient-dependent phosphate transport in renal brush border membrane vesicles. J Biol Chem 1981;256:1556.

    Google Scholar 

  109. Donsa TP, Kempson SA. Regulation of renal brush border membrane transport of phosphate. Miner Electrolyte Metab 1982;7:113.

    Google Scholar 

  110. Tenenhouse HS. Cellular and molecular mechanisms of renal phosphate transport. J Bone Miner Res 1997;12:159-164.

    Google Scholar 

  111. Dennis VW, Stead WW, Myers JL. Renal handling of phosphate and calcium. Annu Rev Physiol 1979;41:257.

    Google Scholar 

  112. Tenenhouse HS, Roy S, Martel J, Gauthier C. Differential expression, abundance, and regulation of Na+-phosphate cotransporter genes in murine kidney. Am J Physiol 1998;275:F527-F534.

    Google Scholar 

  113. Lipman ML, Panda D, Bennett HPJ, Henderson JE, Shane E, Shen Y, Goltzman D, Karaplis AC. Cloning of human PEX cDNA: Expression, subcellular localization and endopeptidase activity. J Biol Chem 1998;273:13729-13737.

    Google Scholar 

  114. Lobaugh B, Burch WM, Jr. Drezner MK. Abnormalities of vitamin D metabolism and action in the vitamin D resistant rachitic and osteomalacic diseases. In: Kumar R, ed. Vitamin D. Boston: Martinus Nijhoff, 1984;665-720.

    Google Scholar 

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    Marc K. Drezner

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Drezner, M.K. Tumor-Induced Osteomalacia. Rev Endocr Metab Disord 2, 175–186 (2001). https://doi.org/10.1023/A:1010006811394

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