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The effect of water deprivation on the pharmacokinetics of antipyrine and sulphadimidine following intravenous administration in Nubian goats

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Abstract

The effect of water deprivation on the pharmacokinetic parameters of antipyrine and sulphadimidine in the Nubian goat was studied. Water deprivation, to a level of dehydration at which the animals lost an average of 7.5% body weight, resulted in a significant reduction in antipyrine clearance (p<0.05), and a consequently increased AUC value (p<0.05). No effect was observed on the distribution parameters of the drug. In dehydrated animals which had lost an average of 10% or 12.5% of their body weight owing to water deprivation, significant changes were found in the distribution and elimination pharmacokinetic parameters of antipyrine and sulphadimidine. The volume of distribution was significantly decreased, resulting in elevated plasma levels for the two drugs compared to normally watered animals. Significant decreases in clearance and subsequent prolongation of the elimination half-lives were observed during these periods of water deprivation. These changes in the disposition kinetics of the two drugs may be attributed to the loss of total body water and extracellular fluids and changes in the liver and kidney functions taking place during dehydration.

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REFERENCES

  • Alaku, O. and Moruppa, S.M., 1983. Dry season weight loss in Red Sokoto (Maradi) goats reared in the Sahel region of North-east Nigeria. International Journal of Biometeorology, 27, 143–156

    Google Scholar 

  • Baggot, J.D., 1977. Principles of Drug Disposition in Domestic Animals, (W.B. Saunders, Philadelphia)

    Google Scholar 

  • Bakar, S.K. and Niazi, S., 1983. Effect of water deprivation on aspirin disposition kinetics. Journal of Pharmaceutical Sciences, 72, 1030–1034

    Google Scholar 

  • Ben-Zvi, Z., Rubin, M., Creveld, C.V. and Yagil, R., 1995. Antipyrine disposition in the dehydrated camel. Journal of Veterinary Pharmacology and Therapeutics, 18, 137–140

    Google Scholar 

  • Branch, R.A., Shand, D.G., Wilkinson, G.R. and Nies, A.S., 1974. Increased clearance of antipyrine and d-propanol after phenobarbitone treatment in the monkey. Journal of Clinical Investigations, 53, 1101–1107

    Google Scholar 

  • Bratton, A.C. and Marshall, E.K., 1939. A new coupling component for sulphadimidine determination. Journal of Biological Chemistry, 128, 537–550

    Google Scholar 

  • Brodie, B.B., Axelrod, J., Soberman, R. and Levy, B.B., 1949. The estimation of antipyrine in biological materials. Journal of Biological Chemistry, 179, 25–29

    Google Scholar 

  • Danhof, M. and Teunissen, M.W., 1984. Antipyrine as a model drug to assess oxidative drug metabolising enzymes in man. Pharmacy International, 5, 11–15

    Google Scholar 

  • El-Hadi, H.M., 1986. The effect of dehydration of Sudanese Desert sheep and goats. Journal of Agricultural Science, UK, 106, 17–20

    Google Scholar 

  • Gad, S. and Weil, C.S., 1986. Statistics and Experimental Design for Toxicologists, (The Telford Press, Caldwell, NJ)

    Google Scholar 

  • Gavrielli, R., Yagil, R., Ziv, G., Creveld, C.V. and Glickman, A., 1995. Effect of water deprivation on the disposition kinetics of enrofloxacin in camels. Journal of Veterinary Pharmacology and Therapeutics, 18, 333–339

    Google Scholar 

  • Gibaldi, M. and Perrier, D., 1982. Pharmacokinetics, 2nd edn, (Marcel Dekker, New York)

    Google Scholar 

  • Houpt, T.R., 1977. Dukes Physiology of Domestic Animals, 9th edn, (Cornell University Press, London)

    Google Scholar 

  • Hunter, R.P., Brown, S.A., Rollins, J.K. and Nelligan, D.F., 1991. The effects of experimentally induced bronchopneumonia on the pharmacokinetics and tissue depletion of gentamicin in healthy and pneumonic calves. Journal of Veterinary Pharmacology and Therapeutics, 14, 276–292

    Google Scholar 

  • Konig, P.K. and Cantilena, L., 1994. Antipyrine as a model drug substance to assess oxidative metabolism. Archives of Internal Medicine, 154, 590–591

    Google Scholar 

  • Lee, D.H.K. and Robinson, K., 1941. Reactions of the sheep to hot atmospheres. Proceedings of the Royal Society, Queensland, 53, 189–200

    Google Scholar 

  • Loft, S., 1990. Metronidazole and antipyrine as probes for the study of foreign compound metabolism. Pharmacology and Toxicology, 66(supplement 6), 1–31

    Google Scholar 

  • Mohamed, S.M., Ali, B.H. and Hassan, T., 1988. Some effects of water deprivation on Dorcas gazelle (Gazella dorcas) in the Sudan. Comparative Biochemistry and Physiology, 90A, 225–228

    Google Scholar 

  • Mousa, H.M. and Elkalifa, M.Y., 1992. Effects of water deprivation on dry matter intake, dry matter digestibility and nitrogen retention in Sudan desert lambs and kids. Small Ruminant Research, 6, 311–316

    Google Scholar 

  • Nawaz, M., 1982. Factors affecting disposition kinetics of sulphadimidine in animals. In: Abstracts, Second Congress of the European Association for Veterinary Pharmacology and Toxicology, Toulouse, 1982, (Pharmacologie et Toxicologie Vé té rinaires, publication No. 8, INRA, Paris), 193–194

    Google Scholar 

  • Nawaz, M. and Nawaz, R., 1983. Pharmacokinetics and urinary excretion of sulphadimidine in sheep during summer and winter. Veterinary Record, 112, 379–381

    Google Scholar 

  • Ohya, M., 1965. Experimental studies on dehydration in ruminants. II. Fluctuation of various phases of body fluids in goats under prolonged water restriction. Japanese Journal of Veterinary Science, 27, 41–54

    Google Scholar 

  • Soberman, R., Brodie, B.B., Levy, B.B., Axelrod, J., Hollander, V. and Steele, J.M., 1949. The use of antipyrine in the measurement of total body water in man. Journal of Biological Chemistry, 179, 31–42

    Google Scholar 

  • Vesell, E.S., 1979. The antipyrine test in clinical pharmacology: conceptions and misconceptions. Clinical Pharmacology and Therapeutics, 26, 275–286

    Google Scholar 

  • Yagil, R., 1993. Renal function and water metabolism in the dromedary. Moving points in nephrology. Contributions to Nephrology, 102, 161–170

    Google Scholar 

  • Yagil, R., Sod-Morash, U.A. and Meyerstein, N., 1974. Dehydration and camel blood. American Journal of Physiology, 226, 298–308

    Google Scholar 

  • Yagil, R., Creveld, C.V., Ben-Zvi, Z., Glickman, A. and Ziv, G., 1994a. Disposition kinetics of chloramphenicol in normal and dehydrated camels. In: Proceedings of the 6th International Congress of the European Association for Veterinary Pharmacology and Toxicology, Edinburgh, 1994, 62–63

  • Yagil, R., Creveld, C.V., Yaaran, A., Glickman, A. and Ziv, G., 1994b. Disposition kinetics of oxytetracycline in normal and dehydrated camels. In: Proceedings of the 6th International Congress of the European Association for Veterinary Pharmacology and Toxicology, Edinburgh, 1994, 101–102

  • Ziv, G., Ben-Zvi, Z., Yagil, R., Creveld, C.V. and Glickman, A., 1991. Disposition kinetics of gentamicin in the normal and dehydrated camel. Acta Veterinaria Scandinavica, 87, 110–113

    Google Scholar 

  • Ziv, G., Creveld, C.V., Ben-Zvi, Z., Glickman, A. and Yagil, R., 1995. Disposition kinetics of tylosin tartrate administered intravenously and intramuscularly to normal and water-deprived camels. Journal of Veterinary Pharmacology and Therapeutics, 181, 299–305

    Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, Pharmacology and Toxicology, Faculty of Veterinary Science, University of Khartoum, PO Box 32, Khartoum North, Sudan

    H.A. Elsheikh & I.A.M. Osman

  2. Department of Biomedical Science, Faculty of Biomedical and Health Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor Darul Ehsan, Malaysia

    A.S. Abdullah

Authors
  1. H.A. Elsheikh
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  2. I.A.M. Osman
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  3. A.S. Abdullah
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Elsheikh, H., Osman, I. & Abdullah, A. The effect of water deprivation on the pharmacokinetics of antipyrine and sulphadimidine following intravenous administration in Nubian goats. Vet Res Commun 21, 587–597 (1997). https://doi.org/10.1023/A:1005975016275

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