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New method for the annelation of the pyridine fragment to azines

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Abstract

The reaction of quinoxaline-2-carbaldehyde with ethyl (E)-3-aminocrotonate afforded ethyl 4-oxo-1,4-dihydropyrido[2,3-b]quinoxaline-3-carboxylate, which is a structural analog of nalidixic and 4-quinolone-3-carboxylic acids representing the basis of the known antibacterial drugs of the fluoroquinolone series.

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Authors and Affiliations

  1. Urals State Technical University, 19 ul. Mira, 620002 Ekaterinburg, Russian Federation, Russia

    V. N. Charushin, A. M. Boguslavsky & M. G. Ponizovsky

  2. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 20 ul. S. Kovalevskoi, 620219 Ekaterinburg, Russian Federation, Russia

    M. I. Kodess

  3. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Russian Federation, Russia

    A. N. Chekhlov, Sh. G. Mkoyan & S. M. Aldoshin

Authors
  1. V. N. Charushin
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  2. A. M. Boguslavsky
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  3. M. G. Ponizovsky
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  4. M. I. Kodess
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  5. A. N. Chekhlov
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  6. Sh. G. Mkoyan
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  7. S. M. Aldoshin
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Charushin, V.N., Boguslavsky, A.M., Ponizovsky, M.G. et al. New method for the annelation of the pyridine fragment to azines. Russian Chemical Bulletin 53, 1267–1271 (2004). https://doi.org/10.1023/B:RUCB.0000042285.01674.58

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  • DOI: https://doi.org/10.1023/B:RUCB.0000042285.01674.58

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