Abstract
We studied a protective effect of a course injections of melatonin on cognitive deficiency in rats with streptozotocin-induced diabetes (STZD). The mean time necessary for the fulfillment of the Morris' water test in animals with STZD after 7 days of testing was three times greater than the corresponding index in the control group. Rats with STZD, which were injected with 10 mg/kg melatonin daily for 21 days after introduction of STZ, demonstrated a significantly lower level of cognitive deficiency ((in these rats the mean time necessary for the test fulfillment was only 48% greater than that in the control animals). In rats with STZD, substantial changes in the content of NCAM isoforms in the brain structures (significant decreases in the NCAM180 content in the hippocampus, neocortex, and cerebellum, and in that of NCAM140 in the cerebellum) were observed. Course injections of melatonin into the rats with STZD promoted significant normalization of the composition of NCAM isoforms in the structures under study. The data obtained indicate that control of expression of separate NCAM isoforms can be one of the mechanisms through which melatonin prevents the development of cognitive deficiency in diabetic animals.
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Nedzvetsky, V.S., Nerush, P.A. & Kirichenko, S.V. Effect of Melatonin on Cognitive Ability of Rats and Expression of NCAM in the Brain Structures in Streptozotocin-Induced Diabetes. Neurophysiology 35, 422–427 (2003). https://doi.org/10.1023/B:NEPH.0000024603.71459.f9
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DOI: https://doi.org/10.1023/B:NEPH.0000024603.71459.f9