Skip to main content
SpringerLink
Log in

DSC and adiabatic calorimetry study of the polymorphs of paracetamol

  • Published:
Journal of Thermal Analysis and Calorimetry Aims and scope Submit manuscript

Abstract

Monoclinic (I) and orthorhombic (II) polymorphs of paracetamol were studied by DSC and adiabatic calorimetry in the temperature range 5 - 450 K. At all the stages of the study, the samples (single crystals and powders) were characterized using X-ray diffraction. A single crystal → polycrystal II→ I transformation was observed on heating polymorph II, after which polymorph I melted at 442 K. The previously reported fact that the two polymorphs melt at different temperatures could not be confirmed. The temperature of the II→I transformation varied from crystal to crystal. On cooling the crystals of paracetamol II from ambient temperature to 5 K, a II→ I transformation was also observed, if the 'cooling-heating' cycles were repeated several times. Inclusions of solvent (water) into the starting crystals were shown to be important for this transformation. The values of the low-temperature heat-capacity of the I and II polymorphs of paracetamol were compared, and the thermodynamic functions calculated for the two polymorphs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. E. Marti, E. Kaiserberger and G. Kaiser (Eds), Thermoanalytical Characterization of Pharmaceuticals, Netzsch Annual 2000, Netzsch-Geraetebau GmbH, 12 (2000), Selb, p. 29.

  2. M. Haisa, S. Kashino and H. Maeda, Acta Crystallogr., B30 (1974) 2510.

    Google Scholar 

  3. M. Haisa, S. Kashino, R. Kawai and H. Maeda, Acta Crystallogr., B32 (1976) 1283.

    CAS  Google Scholar 

  4. G. Nichols and C. S. Frampton, J. Pharm. Sci., 87 (1998) 684.

    Article  CAS  Google Scholar 

  5. D. Yu. Naumov, M. A. Vasilchenko and J. A. K. Howard, Acta Crystallogr., C54 (1998) 653.

    CAS  Google Scholar 

  6. C. C. Wilson, Z. Kristallogr., 215 (2000) 693.

    CAS  Google Scholar 

  7. E. V. Boldyreva, T. P. Shakhtshneider, M. A. Vasilchenko, H. Ahsbahs and H. Uchtmann, Acta Crystallogr., B56 (2000) 299.

    CAS  Google Scholar 

  8. T. N. Drebushchak and E. V. Boldyreva, Z. Kristallogr., 219 (2004) in press.

  9. P. DiMartino, A.-M. Guyot-Hermann, P. Conflant, M. Drache and J.-C. Guyot, Int. J. Pharm., 128 (1996) 1.

    Article  Google Scholar 

  10. F. N. de Wet, J. J. Gerber, A. P. Lötter, J. G. van der Watt and T. G. Dekker, Drug. Dev. Ind. Pharm., 24 (1998) 447.

    Article  CAS  Google Scholar 

  11. E. V. Boldyreva, T. P. Shakhtshneider, H. Ahsbahs, H. Sowa and H. Uchtmann, J. Therm. Anal. Cal., 68 (2002) 437.

    Article  CAS  Google Scholar 

  12. P. DiMartino, P. Conflant, M. Drache, J.-P. Huvenne and A.-M. Guyot-Hermann, J. Thermal Anal., 48 (1997) 447.

    Article  CAS  Google Scholar 

  13. M. Szelagiewicz, C. Marcolli, S. Cianferani, A. P. Hard, A. Vit, A. Burkhard, M. von Raumer, U. C. Hofmeier, A. Zillan, E. Francotte and R. Schenker, J. Therm. Anal. Cal., 57 (1999) 23.

    Article  CAS  Google Scholar 

  14. J. Barra, F. Kubel and E. Doelker, Book of Abstracts, 3rd Symposium on Pharmacy and Thermal Analysis, Ascona, Switzerland 1997, 2PO.

    Google Scholar 

  15. P. Conflant and A. M. Guyot-Hermann, Eur. J. Pharm. Biopharm., 40 (1994) 388.

    CAS  Google Scholar 

  16. E. Marti, J. Thermal Anal., 33 (1988) 37.

    Article  Google Scholar 

  17. E. V. Boldyreva, V. A. Drebushchak, T. N. Drebushchak, I. E. Paukov, Y. A. Kovalevskaya and E. S. Shutova, J. Therm. Anal. Cal., 73 (2003) 409.

    Article  CAS  Google Scholar 

  18. E. V. Boldyreva, V. A. Drebushchak, T. N. Drebushchak, I. E. Paukov, Y. A. Kovalevskaya and E. S. Shutova, J. Therm. Anal. Cal., 73 (2003) 419.

    Article  CAS  Google Scholar 

  19. V. A. Drebushchak, M. A. Mikhailenko, E. V. Boldyreva, T. N. Drebushchak, T. P. Shakhtshneider and V. V. Boldyrev, Book of Abstracts of the 7th International Conference on Pharmacy and Applied Physical Chemistry (PhandTA 7), Innsbruck, 7–11 September 2003. P. PO 17.

  20. M. A. Mikhailenko, J. Cryst. Growth, 265 (2004) 616.

    Article  CAS  Google Scholar 

  21. V. G. Bessergenev, Yu. A. Kovalevskaya, I. E. Paukov and Yu. A. Shkredov, Thermochim. Acta, 139 (1989) 245.

    Article  CAS  Google Scholar 

  22. V. G. Bessergenev, Yu. A. Kovalevskaya, I. E. Paukov, M. A. Starikov, H. Opperman and W. Reichelt, J. Chem. Thermodynam., 24 (1992) 85.

    Article  CAS  Google Scholar 

  23. A. Burger and R. Ramberger, Microchim. Acta II, (1979) 273.

  24. V. A. Drebushchak, Yu. A. Kovalevskaya, I. E. Paukov and E. V. Boldyreva, J. Therm. Anal. Cal., 74 (2003) 109.

    Article  CAS  Google Scholar 

  25. V. A. Drebushchak, E. V. Boldyreva, Yu. A. Kovalevskaya, I. E. Paukov and T. N. Drebushchak, J. Therm. Anal. Cal., 2004, accepted.

Download references

Author information

Authors and Affiliations

  1. Research and Education Center 'Molecular Design and Ecologically Safe Technologies, REC-008, Novosibirsk State University, ul. Pirogova, 2, Novosibirsk, 630090, Russia

    Elena V Boldyreva & Tatiana N Drebushchak

  2. Institute of Mineralogy and Petrography, Siberian Branch of the Russian Academy of Sciences, pr. Koptyuga, 3, Novosibirsk, 630090, Russia

    V. A. Drebushchak

  3. Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, pr. Lavrent'eva, 3, Novosibirsk, 630090, Russia

    I. E. Paukov & Yulia A. Kovalevskaya

Authors
  1. Elena V Boldyreva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. A. Drebushchak
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I. E. Paukov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yulia A. Kovalevskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tatiana N Drebushchak
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Boldyreva, E.V., Drebushchak, V.A., Paukov, I.E. et al. DSC and adiabatic calorimetry study of the polymorphs of paracetamol. Journal of Thermal Analysis and Calorimetry 77, 607–623 (2004). https://doi.org/10.1023/B:JTAN.0000038998.47606.27

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/B:JTAN.0000038998.47606.27

Search

Navigation