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The Effect of Exercise on Platelet Aggregability and Lipid Peroxidation

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Abstract

The effects of single bicycle ergometric exercises of a moderate or high intensity on platelet ADP-dependent aggregation, content of malonic dialdehyde (MDA), and activity of catalase were studied in young men with relatively high working capacities. Platelet aggregability either increased or decreased in response to the exercise. Hyperaggregation was recorded in about two-thirds of the subjects and hypoaggregation, in one-third. Changes in the aggregation parameters correlated with their basal values at rest. Muscular activity raised the aggregability of platelets when it was initially low and lowered it when it was initially high. An increased intensity of exercise made these correlations stronger. The exercise-caused changes in the MDA content in platelets also correlated with its basal level. A low MDA content at rest increased, and an initially high MDA content decreased. The response of hypoaggregation was associated with moderate and strong correlations between the basal content of MDA and catalase activity in platelets and the exercise-induced changes in the MDA content and platelet aggregability. It was concluded that a high basal level of MDA in platelets is a factor decreasing platelet aggregability during muscular activity.

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REFERENCES

  1. Bourey, R.E. and Santoro, S.A., Interactions of Exercise, Coagulation, Platelets, and Fibrinolysis—A Brief Review, Med. Sci. Sports Exerc., 1988, vol. 20, no. 5, p. 439.

    Google Scholar 

  2. El-Sayed, M.S., Sale, C., Jones, P.G., and Chester, M., Blood Hemostasis in Exercise and Training, Med. Sci. Sports Exerc., 2000, vol. 32, no. 5, p. 918.

    Google Scholar 

  3. Shiryaev, V.V. and Shiryaev, N.V., Changes in Erythrocytes during Exercise, Fiziol. Chel., 1994, vol. 20, no. 4, p. 168.

    Google Scholar 

  4. Lapshina, M.V. and Golyshenkov, S.P., The Effect of Dosed Exercise on the Coagulating Potential of Erythrocytes and Some Parameters of Red Blood, in Voprosy medico-biologicheskikh nauk. Issue 2. Morfofunktsional'nye i biokhimicheskie aspeckty adaptatsii(Problems of Biomedical Sciences: Issue 2. Morphofunctional and Biochemical Aspects of Adaptation), Saransk, 1997, p. 42.

  5. Golyshenkov, S.P. and Lapshina, M.V., Exercise-induced Changes in Fibrinolytic Properties of Erythrocytes, Fiziol. Chel., 2000, vol. 26, no. 1, p. 77.

    Google Scholar 

  6. El-Sayed, M.S., Effects of Exercise on Blood Coagulation, Fibrinolysis, and Platelet Aggregation, Sports Med., 1996, vol. 22, no. 5, p. 282.

    Google Scholar 

  7. Wang, J.S., Jen, C.J., Kung, H.C., et al., Different Effects of Strenuous Exercise and Moderate Exercise on Platelet Function in Men, Circulation, 1994, vol. 90, no. 6, p. 2877.

    Google Scholar 

  8. Khalfen, E.Sh., Lyamina, N.P., and Meerson, F.Z., Comparative Assessment of the Stress and Exercise Effects on Blood Coagulation in Healthy Persons and Patients with Ischemic Heart Disease, Ter. Arkh., 1990, vol. 62, no. 8, p. 50.

    Google Scholar 

  9. Ayushiev, O.D., Kuznik, B.I., and Tsybikov, N.N., The Effect of Platelet-released Polypeptides on Immunity and Hemostasis, Sechenov Fiziol. Zh., 1995, vol. 81, no. 7, p. 80.

    Google Scholar 

  10. Tozzi-Ciancarelli, M.G., Penco, M., and Di Massimo, C., Influence of Acute Exercise on Human Platelet Responsiveness: Possible Involvement of Exercise-induced Oxidative Stress, Eur. J. Appl. Physiol., 2002, vol. 86, no. 3, p. 266.

    Google Scholar 

  11. Vrzhets, P.V., Tatarintsev, A.V., Orlova, E.V., et al., Kinetics of Merthiolate-induced Aggregation of Human Platelets, Biokhimiya, 1992, vol. 57, no. 3, p. 506.

    Google Scholar 

  12. Shatilina, L.V., Lipid Peroxidation as a Mechanism Regulating the Platelet Aggregability, Kardiologiya, 1993, no. 10, p. 25.

  13. Donneli, A.E., Glesson, M., Maughan, R.J., et al., Delayed-Onset Rise in Serum Lipid Peroxide Concentration Following Eccentric Exercise in Man, J. Physiol., 1987, vol. 392, p. 51.

    Google Scholar 

  14. Factor, E.A., Lipid Peroxidation in Exercise and Its Correction by Exogenous Agents for Increasing the Physical Working Capacity of Athletes, Doctoral (Biol.) Dissertation, St. Petersburg, 1995.

  15. Kurguzova, N.V. and Golyshenkov, S.P., The Effect of Dosed Exercise on Some Parameters of Lipid Metabolism, in Voprosy mediko-biologicheskikh nauk: Sbornik statei po mater. nauch. konf. XXXII Evsev'ev chteniya (Problems of Biomedical Sciences: Papers of the Scientific Conf. XXXII Evsev'ev Readings), Saransk, 1996, p. 38.

  16. Karpman, V.L., Belotserkovskii, Z.B., and Gudkov, I.A., Testirovanie v sportivnoi meditsine (Testing in Sports Medicine), Moscow: Fizkul'tura i Sport, 1988, p. 75.

    Google Scholar 

  17. Baluda, V.P., Barkagan, Z.S., Goldberg, E.D., et al., Laboratornye metody issledovaniya sistemy gemostaza (Laboratory Methods for Investigating the Hemostasis System), Tomsk, 1980, p. 84.

  18. Konyukhova, S.G., Dubikaitis, A.Yu., and Shabunevich, L.V., The Role of Activation of Peroxidation in Pathogenesis of Experimental Peritonitis, Byull. Eksp. Biol. Med., 1989, vol. 107, no. 5, p. 557.

    Google Scholar 

  19. Korolyuk, M.A., Ivanova, A.I., Maiorova, I.G., and Tokarev, V.E., A Method for Determination of Catalase Activity, Lab. Delo, 1988, no. 1, p. 16.

  20. Varfolomeev, S.A. and Mevkh, A.T., Prostaglandiny— molekulyarnye bioregulyatory(Prostaglandins as Molecular Bioregulators), Moscow: Mosk. Gos. Univ., 1985.

    Google Scholar 

  21. Barkagan, Z.S., Gemorragicheskie zabolevaniya i sindromy (Hemorrhagic Diseases and Syndromes), Moscow: Meditsina, 1988, 2nd ed., p. 12.

    Google Scholar 

  22. Hollister, A.S., Onrot, J., Lonce, S., et al., Plasma Catecholamine Modulation of α2 Adrenoreceptor Agonist Affinity and Sensitivity in Normotensive and Hypertensive Human Platelets, J. Clin. Invest. 1986, vol. 77, no. 5, p. 1416.

    Google Scholar 

  23. Jones, C.R., Elliott, H.L., Deighton, N., et al., α-Adrenoreceptor Number and Function in Platelets from Treated and Untreated Patients with Essential Hypertension and Age-and Sex-Matched Controls, J. Hypertens. Suppl., 1985, suppl. 3, p. 153.

  24. Owen, N.E., Feinberg, H., and Le Breton, G.C., Epinephrine Induces Ca2+ Uptake in Human Blood Plate-lets, Am. J. Physiol., 1980, vol. 239, no. 4, p. H483.

    Google Scholar 

  25. Block, L.H., Jacksche, H., Erne, P., et al., (–)-Adrenaline induced Calcium-dependent Phosphorylation of Proteins in Human Platelets, J. Clin. Invest., 1985, vol. 75, no. 5, p. 1600.

    Google Scholar 

  26. Alexandre, A., Doni, M.G., Padoin, E., and Deana, R., Inhibition by Antioxidants of Agonist Evoked Cytosolic Ca ++ Increase, ATP Secretion, and Aggregation of Aspirinated Human Platelets, Biochem. Biophys. Res. Commun., 1986, vol. 139, no. 2, p. 509.

    Google Scholar 

  27. Gavrilov, O.K. and Kaveshnikova, B.F., The Role of Prostaglandins in the RASK System, in Problemy i gipotezy v uchenii o svertyvanii krovi(Problems and Hypotheses in the Doctrine on Blood Coagulation), Moscow: Meditsina, 1981, p. 75.

    Google Scholar 

  28. Tschopp, T.B. and Baumgartner, H.R., Platelet Adhesion and Mural Platelet Thrombus Formation on Aortic Subendothelium of Rats, Rabbits, and Guinea Pigs Correlate Negatively with the Vascular PGI 2Production, J. Lab. Clin. Med., 1981, vol. 98, no. 3, p. 402.

    Google Scholar 

  29. Heijnen, H.F.G., Waaijeborg, S., den Dekker, E., and Akkerman, J.-W.N., Subcellular Localization of cAMP-dependent PKA in Platelets, Megakaryocytes, and Endothelial Cells: A Clue for Their Functioning, Plate-lets, 2002, vol. 13, no. 1, p. 48.

    Google Scholar 

  30. Samal, A.B., Cherenkevich, S.N., and Khmara, N.F., The Role of Reactive Oxygen Species in Platelet Aggregation and Disaggregation, Biokhimiya, 1990, vol. 55, no. 5, p. 786.

    Google Scholar 

  31. Petersen, P.L.J., Mitochondrial Averts in the Life and Death of Animal Cells, Bioenerg. Biomembr., 1999, vol. 31, no. 4, p. 291.

    Google Scholar 

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Authors and Affiliations

  1. Evsev'ev Mordovian State Pedagogical Institute, Saransk, 430000, Russia

    S. P. Golyshenkov, N. A. Mel'nikova & M. V. Lapshina

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  1. S. P. Golyshenkov
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  2. N. A. Mel'nikova
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  3. M. V. Lapshina
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Golyshenkov, S.P., Mel'nikova, N.A. & Lapshina, M.V. The Effect of Exercise on Platelet Aggregability and Lipid Peroxidation. Human Physiology 30, 708–713 (2004). https://doi.org/10.1023/B:HUMP.0000049592.44947.39

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