Skip to main content
SpringerLink
Log in

Prevalence of Non-Organ-Specific Autoantibodies in Patients Suffering from Duodenal Ulcer With and Without Helicobacter pylori Infection

  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

Autoimmunity, a feature of chronic infection by Helicobacter pylori, is first directed against gastric cells but is also associated with extragastric diseases. The aim of the present work was to look for the influence of the infection on induction of non-organ-specific autoantibodies (NOSAs). We compared 49 patients (28 males and 21 females; age range, 36–72 years; mean, 61 ± 4.6 years) suffering from duodenal ulcer and H. pylori infection (Group A) to 38 subjects (20 male, 18 female; age range, 40–78 years; mean, 63 ± 3.8 years) affected by duodenal ulcer related to the assumption of nonsteroidal antiinflammatory drugs (Group B). H. pylori infection was diagnosed by histology, 13C-urea breath test, and serum IgG antibodies. Autoimmunitary pattern was demonstrated by the presence of NOSAs in serum. Antinuclear (ANA), anti-smooth muscle (SMA), and anti-liver/kidney microsomal-1 (LKM-1) antibodies were present in 5 of 49 (10.2%), 2 of 49 (4%), and 0 Group A patients, respectively. In Group B, ANA was present in 3 of 38 (7.9%), SMA in 3 of 38 (7.9%), and anti-LKM-1 in 0 patients. The difference was not statistically significant. In this population, H. pylori infection is not associated with an increased prevalence of NOSAs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Suerbaum S, Michetti P: Helicobacter pylori infection. N Engl J Med 347:1175-1186, 2002

    Google Scholar 

  2. Panchal PC, Forman JS, Blumberg DR, Wilson KT: Helicobacter pylori infection: pathogenesis. Curr Opin Gastroenterol 19:4-10, 2003

    Google Scholar 

  3. Moran AP, Prendergast MM: Molecular mimicry in Campylobacter jejuni and Helicobacter pylori lipopolysaccharides: contribution of gastrointestinal infections to autoimmunity. J Autoimmun 16:241-256, 2001

    Google Scholar 

  4. Zentilin P, Seriolo B, Dulbecco P, Caratto E, Iiritano E, Fasciolo D, Bilardi C, Mansi C, Testa E, Savarino V: Eradication of Helicobacter pylori may reduce disease severity in rheumatoid arthritis. Aliment Pharmacol Ther 16:1291-1299, 2002

    Google Scholar 

  5. Figura N, Di Cairano G, Lore F, Guarino E, Gragnoli A, Cataldo D, Giannace R, Vaira D, Bianciardi L, Kristodhullu S, Lenzi C, Torricelli V, Orlandini G, Gennari C: The infection by Helicobacter pylori strains expressing CagA is highly prevalent in women with autoimmune thyroid disorders. J Physiol Pharmacol 50:817-826, 1999

    Google Scholar 

  6. Veneri D, Franchini M, Gottardi M, D'Adda M, Ambrosetti A, Krampera M, Zanetti F, Pizzolo G: Efficacy of Helicobacter pylori eradication in raising platelet count in adult patients with idiopathic thrombocytopenic purpura. Haematologica 87:1177-1179, 2002

    Google Scholar 

  7. Durazzo M, Pellicano R, Premoli A, Berrutti M, Leone N, Ponzetto A, Rizzetto M: Helicobacter pylori seroprevalence in patients with autoimmune hepatitis. Dig Dis Sci 47:380-383, 2002

    Google Scholar 

  8. International Autoimmune Hepatitis Group Report: Review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 31:929-938, 1999

  9. Durazzo M, Philipp T, Van Pelt FNAM, Luttig B, Borghesio E, Michel G, Schmidt E, Loges S, Rizzetto M, Manns MP: Heterogeneity of liver-kidney microsomal autoantibodies in chronic hepatitis C and D virus infection. Gastroenterology 108:455-462, 1995

    Google Scholar 

  10. Danielli E: A fluorometric enzyme-linked immunosorbent assay for serological diagnosis of Helicobacter pylori infection. Eur J Gastroenterol Hepatol 5 (Suppl 2):S57-S59, 1993

    Google Scholar 

  11. Medina J., García-Buey L., Moreno-Otero, R: Immunopathogenetic and therapeutic aspects of autoimmune hepatitis. Aliment Pharmacol Ther 17:1-16, 2003

    Google Scholar 

  12. Negrini R: Is autoimmunity involved in the relationship between Helicobacter pylori infection, atrophic gastritis and gastric cancer? Ital J Gastroenterol Hepatol 31:842-845, 1999

    Google Scholar 

  13. Macchia G, Massone A, Burroni D, Covacci A, Censini S, Rappuoli R: The Hsp60 protein of Helicobacter pylori: structure and immune response in patients with gastroduodenal diseases. Mol Microbiol 9:645-652, 1993

    Google Scholar 

  14. Faller G, Kirchner T: Role of antigastric autoantibodies in chronic Helicobacter pylori infection. Microsc Res Tech 48:321-326, 2000

    Google Scholar 

  15. Pellicano R, Rizzetto M: Extragastric manifestations of Helicobacter species infections. Do these bacteria act as triggers? Minerva Gastroenterol Dietol 48:179-187, 2002

    Google Scholar 

  16. Sepulveda AR, Coelho LGV: Helicobacter pylori and gastric malignancies. Helicobacter 7:37-42, 2002

    Google Scholar 

  17. Franceschi F, Sepulveda AR, Gasbarrini A, Pola P, Gentiloni Silveri N, Gasbarrini G, Graham DY, Genta RM: Cross-reactivity of anti-CagA antibodies with vascular wall antigens. Possible pathogenic link between Helicobacter pylori infection and atherosclerosis. Circulation 106:430-434, 2002

    Google Scholar 

  18. Birnie DH, Holme ER, McKay IC, Hood S, McColl KEL, Hillis WS. Association between antibodies to heat shock protein 65 and coronary atherosclerosis. Possible mechanism of action of Helicobacter pylori and other bacterial infections in incresing cardiovascular risk. Eur Heart J 19:387-394, 1998

    Google Scholar 

  19. Nagashima R, Maeda K, Yuda F, Kudo K, Saitoh M, Takahashi T: Helicobacter pylori antigen in the glomeruli of patients with membranous nephropathy. Virchows Arch 431:235-239, 1997

    Google Scholar 

  20. Nevo Y, Pestronk A: Acute immune polyneuropathies: correlations of serum antibodies to Campylobacter jejuni and Helicobacter pylori with anti-GM1 antibodies and clinical patterns of disease. J Infect Dis 176 (Suppl 2):S154-S156, 1997

    Google Scholar 

  21. Sorrentino D, Ferraccioli GF, De Vita S, Labombarda A, Boiocchi M, Bartoli E: Helicobacter pylori infection and autoimmune processes: an emerging field of study. Ital J Gastroenterol Hepatol 30 (Suppl 3):S310-S312, 1998

    Google Scholar 

  22. Lenzi M, Bellentani S, Saccoccio G, Muratori G, Masutti F, Muratori L, Cassani F, Bianchi FB, Tiribelli C: Prevalence of non-organ-specific autoantibodies and chronic liver disease in the general population: a nested case-control study of the Dionysos cohort. Gut 45(3):435-441, 1999

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The UOADU Gastro-Hepatology, Molinette Hospital, Turin, Italy

    Rinaldo Pellicano, Giovanni Antonio Touscoz, Antonina Smedile, Mara Berrutti, Giorgio Saracco, Alessandro Repici, Antonio Ponzetto & Mario Rizzetto

Authors
  1. Rinaldo Pellicano
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Giovanni Antonio Touscoz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Antonina Smedile
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mara Berrutti
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Giorgio Saracco
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Alessandro Repici
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Antonio Ponzetto
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Mario Rizzetto
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pellicano, R., Touscoz, G.A., Smedile, A. et al. Prevalence of Non-Organ-Specific Autoantibodies in Patients Suffering from Duodenal Ulcer With and Without Helicobacter pylori Infection. Dig Dis Sci 49, 395–398 (2004). https://doi.org/10.1023/B:DDAS.0000020491.78450.82

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/B:DDAS.0000020491.78450.82

Search

Navigation