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Some Chemical Transformations of 4,5-Dihydro-5-methyl-3H-spiro[benz-2-azepine-3,1'-cyclohexane] N-Oxide

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The oxidation and reduction of 4,5-dihydro-5-methyl-3H-spiro[benz-2-azepine-3,1'-cyclohexane] N-oxide, the reactions of this N-oxide with methylmagnesium iodide, the sodium salt of diethyl malonate, phenyl isocyanate, and its rearrangement by the action of acetic anhydride lead to N-hydroxy-1,2,3,4-tetrahydrobenz-2-azepines, benz-2-azepine-1-one, and its N-acetoxy derivative as well as isoxazolidino- and oxadiazolidino[3,2-a]benz-2-azepines spirofused with a cyclohexane ring.

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Authors and Affiliations

  1. Russian People's Friendship University, 117198, Moscow, Russia

    A. V. Varlamov, D. G. Grudinin & A. I. Chernyshev

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  1. A. V. Varlamov
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  2. D. G. Grudinin
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  3. A. I. Chernyshev
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Varlamov, A.V., Grudinin, D.G. & Chernyshev, A.I. Some Chemical Transformations of 4,5-Dihydro-5-methyl-3H-spiro[benz-2-azepine-3,1'-cyclohexane] N-Oxide. Chemistry of Heterocyclic Compounds 40, 622–630 (2004). https://doi.org/10.1023/B:COHC.0000037318.38320.7b

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  • DOI: https://doi.org/10.1023/B:COHC.0000037318.38320.7b

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