Skip to main content
SpringerLink
Log in

HIV-1 gp120 Binding to Dendritic Cell Receptors Mobilize the Virus to the Lymph Nodes, but the Induced IL-4 Synthesis by FcεRI+ Hematopoietic Cells Damages the Adaptive Immunity – a Review, Hypothesis, and Implications

  • Published:
Virus Genes Aims and scope Submit manuscript

Abstract

HIV-1 is equipped with the envelope gp160 glycoprotein for interaction with Langerhans cells (LCs) and dendritic cells (DCs), the members of the innate immune system, which confront the virus at the portal of virus entry in the human body. These cells are equipped with receptors by which they bind and endocytose the virus. The gp120 glycoprotein is used for binding to CD4 receptor and CCR5 co-receptor of T helper 2 (Th2) cells and the virions shed gp120 is able to induce FcεRI+ hematopoietic cells to produce IL-4, which inactivate the host adaptive immune response. The properties of gp120s various functional domains are analyzed together with the regulatory viral proteins, which are involved in the damage to T and B cells during HIV-1 replication. The interaction of HIV-1 virions through their gp120 with LCs and DCs at the portal of virus entry will be discussed. A hypothesis will be presented that the understanding of the role of the different functional domains of gp120 in the life cycle of the virus and during AIDS will help in the design of approaches to prevent and abrogate HIV-1 infection and AIDS.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Sabin A.B., Proc Natl Acad Sci USA 89, 8852–8859, 1992.

    Google Scholar 

  2. (No authors listed), Drugs R D 4, 249–253, 2003.

    Google Scholar 

  3. Leung D.Y.M., Mol Genet Metabol 63, 157–167, 1998.

    Google Scholar 

  4. Albarse R.C., J Allergy Clin Immunol 106, 228–238, 2000.

    Google Scholar 

  5. Patella V., Giuliano A., Bouvet J.P., and Marone G., J Immunol 161, 5647–5655, 1998.

    Google Scholar 

  6. Becker Y., Virus Genes 27, 269–282, 2003.

    Google Scholar 

  7. Becker Y., Virus Genes 28, 1–14, 2004.

    Google Scholar 

  8. Clerici M. and Shearer G.M., Immunol Today 14, 107–111, 1993.

    Google Scholar 

  9. Karray S. and Zouali M., Proc Natl Acad Sci USA 94, 1356–1360, 1997.

    Google Scholar 

  10. Karray S., Juompan L., Maroun R.C., Isenberg D., Silverman G.J., and Zouali M., J Immunol 161, 6681–6688, 1998.

    Google Scholar 

  11. Becker Y., Virus Genes 28, 319–331, 2004.

    Google Scholar 

  12. Zhu P., Chertova F., Bess J. Jr., Lifson J.D., Arthur L.O., Lu J., Taylor X.A., and Roux K.H., Proc Natl Acad Sci USA 100, 15812–15817, 2003.

    Google Scholar 

  13. Adams D. and Scheid A., AIDS Res Human Retroviruses 17, 1345–1356, 2001.

    Google Scholar 

  14. Becker Y., Virus Genes 8, 249–270, 1994.

    Google Scholar 

  15. Srivasata S.K., Stamatatos L., Kan E., Vajdy M. Lian Y., Hilt S., Martin L., et al., J Virol 77, 11244–11259, 2003.

    Google Scholar 

  16. Willey R.L., Bonifacino J.S., Potts B.J., Martin M.A., and Klausner R.D., Proc Natl Acad Sci USA 85, 9580–9584, 1988.

    Google Scholar 

  17. McCune J.M., Rabin L.B., Feinberg M.B., Lieberman M., Kosek J.C., Reyes G.R., and Weissman I.L., Cell 53, 55–67, 1988.

    Google Scholar 

  18. Gelderblom H.R., Hausman E.H.S., Özel M., Pauli G., and Koch M.A., Virology 156, 171–176, 1987.

    Google Scholar 

  19. Wyatt R. and Sodroski J., Science 280, 1884–1888, 1998.

    Google Scholar 

  20. Poignard P., Saphire E.O., Whi Parren P., and Burton D.R., Annu Rev Immunol 19, 253–274, 2001.

    Google Scholar 

  21. Li Y., Luo L., Rasool N., and Kang C.Y., J Virol 67, 584–588, 1993.

    Google Scholar 

  22. Rizzuto C.D., Wyatt R., Hernandez-Ramos N., Sun Y., Kwong P.D., Hendrikson W.A., and Sodroski J., Science 280, 1949–1953, 1998.

    Google Scholar 

  23. Bariband F., Pöxhlman S., and Dons R.W., Virology 286, 1–6, 2001.

    Google Scholar 

  24. Twirville S.G., Arthos J., MacDonald K., Lynch G., Naif H., Clark G., Hart D., and Cunningham A.L., Blood 98, 2482–2488, 2001.

    Google Scholar 

  25. Berberian L., Goodglick L., Kipps T.J., and Braun J., Science 261, 1588–1591, 1993.

    Google Scholar 

  26. Goodglick L., Zevil N., Nesat M.S., and Braun J., J Immunol 155, 5151–5159, 1995.

    Google Scholar 

  27. Juompan L., Lambin P., and Zouali M., FASEB J 12, 1473–1480, 1998.

    Google Scholar 

  28. Florio G. Petraroli A., Patella V., Tiggiani M., and Marone G., AIDS 14, 931–938, 2000.

    Google Scholar 

  29. Takahashi M., Osono E., Nakagaway Y., Wang J., Berzofsky J.A., Margulies D.H., and Takahashi H., J Immunol 169, 6588–6593, 2002.

    Google Scholar 

  30. Javaherian K., Langlois A.J., McDanal C., Ross K.L., Eckler L., Jellis C.L., Profy A.T., Rusche J.R., Bolognesi D.P., Putney S.D., and Matthews T.J., Proc Natl Acad Sci USA 86, 6768–6772, 1989.

    Google Scholar 

  31. Boudet F., Girard M., Theze J., and Zouali M. Int Immunol 4, 283–294, 1992.

    Google Scholar 

  32. Wyatt R., Kwong P.D., Desjardin E., Sweet R.W., Robinson J., Hendrickson W.A., and Sodroski J.G., Nature 393, 705–710, 1998.

    Google Scholar 

  33. Moore J.P., Sattentau Q.J., Yoshiyama H., Thall M., Charles M., Sullivan N., Doon S.-W., Fung M.S., Traincard F., Pinkus M., Robey G., Robinson J.E., Ho D.D., Sodroski J., J Virol 67, 6136–6151, 1993.

    Google Scholar 

  34. Cao J., Sullivan N., Desjardin E., Parolin C., Robinsion J., Wyatt R., and Sodroski Y., J Virol 71, 9808–9812, 1997.

    Google Scholar 

  35. Stamatatos L., Wiskerchen M., and Cheng-Mayer C., AIDS Res Human Retroviruses 14, 1129–1139, 1998.

    Google Scholar 

  36. Kmieciak D., Wasik T.J., Teppler H., Pientka J., Hsu S.H., Takahshi H., Okumura K., Kaneko Y., and Kozbor D., J Immunol 160, 5676–5683, 1998.

    Google Scholar 

  37. Kiszka I., Kmieciak D., Gzyl J., Naito T., Bolesta E., Sieron A., Singh S.P., Srinivasan A., Trinchierti G., Kaneko Y., and Kozbor D., J Virol 76, 4222–4232, 2002.

    Google Scholar 

  38. Garrity R.R., Rimmelzwaan G., Minassian A., Tsai W.P., Lin G., deJong J.J., Goodsmit J., and Nara P.L., J Immunol 159, 279–289, 1997.

    Google Scholar 

  39. Binley J.M., Sanders R.W., Clas B., Schuelke N., Master A., Guo Y., Kajamo F., Anselma D.J., Maddon P.J., Olson W.C., and Moore J.P., J Virol 74, 627–643, 2000.

    Google Scholar 

  40. Edwards T.G., Wyss S., Reeves J.D., Zolla-Pazner S., Hoxie J.A., Doms R.W., and Bariband F., J Virol 76, 2683–2691, 2002.

    Google Scholar 

  41. Prljic J., Veljković N, Doliana R., Colombati A., Johnson E., Metla Ś, and Veljković V., Vaccine 17, 1462–1467, 1999.

    Google Scholar 

  42. de Paulis A., de Palma R., DiGioia L., Carfora M., Prevete N., Tosi G., Accola R.S., and Marone G., J Immunol 165, 7171–7179, 2000.

    Google Scholar 

  43. Pu H., Tian J., Flora G., Lee Y.W., Nath A., Henning B., and Toborek M., Mol Cell Neurosci 24, 224–237, 2003.

    Google Scholar 

  44. Caldwell R.L., Egan B.S., and Shepherd V.L., J Immunol 165, 7035–7041, 2000.

    Google Scholar 

  45. Agwale S.M., Shata M.T. Reitz M.S., Kalyanaraman V.S., Gallo R.C., Popovic M., and Hone D.M., Proc Nat Acad Sci USA 99, 10037–10041, 2002.

    Google Scholar 

  46. Voss G. Manson K. Motefiori D., Watkins D.I., Heeny J., Wyand M., Cohen J., and Bruck C., J Virol 77, 1049–1058, 2003.

    Google Scholar 

  47. Tichonov I., Ruckwardt T.J., Hatfield G.S., and Pauza C.D., J Virol 77, 3157–3166, 2003.

    Google Scholar 

  48. Noonan D.M., Gringeri A., Meazza R., Rosso O., Mazza S., Muca-Perja M., Le Buanec H., Accolla R.S., Albini A., and Ferrini S., J Acquir Immune Defic Syndr 33, 47–55, 2003.

    Google Scholar 

  49. Kim D.T., Mitchell D.J., Brockstedt D.G., Fong L., Nolan G.P., Fathman C.G., Engelman E.G., and Rothbard J.B., J Immunol 159, 1666–1668, 1997.

    Google Scholar 

  50. Kim T.-G. and Langridge W.H.R., Plant Cell Rep 22, 382– 387, 2004.

    Google Scholar 

  51. Tungaturthi P.K., Sawaya B.E., Sing S.P., Tomkowicz B., Ayyavoo V., Khalili K., Collman R.G., Amin S., and Srinivasan A., Biomed Pharmacother 57, 20–24, 2003.

    Google Scholar 

  52. Ayyavoo V., Muthumani K., Kudchodar S., Zhang D., Ramanatan P., Dayes N.S., Kim J.J., Sin J.I., Montaner L.J., and Weiner D.B., Int Immunol 14, 13–22, 2002.

    Google Scholar 

  53. Casortelli N., Di Matteo G., Potesta M., Rossi P., and Doria M., J Virol 77, 11536–11545, 2003.

    Google Scholar 

  54. Salvi R., Garbuglia A.R., Di Carlo A., Pulciani S., Moutella F., and Benedetto A., J Virol 72, 3646–3651, 1998.

    Google Scholar 

  55. Kavanagh D.G. and Bhardwaj N., Nat Immunobiol 3, 891–893, 2002.

    Google Scholar 

  56. Soilleux E.J. and Coleman N., J Clin Pathol 57, 77–78, 2004.

    Google Scholar 

  57. Cambi A., de Lang F., van Moarseveen N.H., Nijhuis M., Joosten B., van Dijk E.M.H.P., de Baaker B.I., et al., J Cell Biol 164, 145–155, 2004.

    Google Scholar 

  58. Kelleher P., Maroof A., and Night S.G., Eur J Immunol 29, 2309–2318, 1999.

    Google Scholar 

  59. Figdor C.G., van Kooyk Y., and Adema G.J., Nat Rev Immunol 2, 77–84, 2002.

    Google Scholar 

  60. Geijtenbeek T.B.H., and van Kooyk Y., APMIS 111, 698–714, 2003.

    Google Scholar 

  61. Liu H., Yu W., Liou L.-Y., and Rice A.P., Gene 313, 149–159, 2003.

    Google Scholar 

  62. Valladeau J., Ravel O., Dezzutter-Dambuyant C., Moore K., Kleijmeer M., Liu Y., et al., Immunity 12, 71–81, 2000.

    Google Scholar 

  63. Birbeck M.S., Breathnach A.S., and Everall J.D., J Invest Dermatol 37, 51–64, 1961.

    Google Scholar 

  64. McDermott R., Ziylan U., Spehner D., Bausinger H., Lipsker D., et al., Mol Biol Cell 13, 317–335, 2002.

    Google Scholar 

  65. Salleisto F., Cella M., Danieli C., and Lanzavecchia A., J Exp Med 182, 389–400, 1995.

    Google Scholar 

  66. Pieters J. Adv Immunol 75, 159–208, 2000.

    Google Scholar 

  67. Engering A., Geijtenbeck T.B., van Vliet S.J., Wijers M., Van Liempt E., et al., J Immunol 168, 2118–2126, 2002.

    Google Scholar 

  68. Larsson M. Fonteneau J.F., and Bhardwaj N., Trends Immunol 22, 141–148, 2001

    Google Scholar 

  69. Moris A., Nobile C., Buseyne F., Porrot F., Abastodo J.-P., and Schwartz O., Blood, October 23, 2003 (prepublished on-line).

  70. Shacklett B.L., Means R.E., Larsson M., Wilkens D.T., Beadle T.J., et al., AIDS Res Human Retroviruses 18, 805–815, 2002.

    Google Scholar 

  71. Rowland-Jones S.L., Dong T., Dorrell L., Ogg G., Hansasuta P., Krausa P., et al., Immunol Lett. 66, 9–14, 1999.

    Google Scholar 

  72. Hong P.W.-F., Flummerfelt K.B., de Parseval A., Gurvey K., Elder I.H., and Lee B., J Virol 76, 12855–12865, 2002.

    Google Scholar 

  73. Feinberg H., Mitchell D.A., Drickamer K., and Weiss W.I., Science 294, 2163–2166, 2001.

    Google Scholar 

  74. Koch M., Pancera M., Kwong P.P., Kolchinsky P., Grudner C., Wang L., Hendrickson W.A., Sodroski J., and Wyatt R., Virology 313, 387–400, 2003.

    Google Scholar 

  75. Calarese D.A., Scanlan C.N., Zwick M.B., Deechongkit S., Mimura Y., et al., Science 300, 2065–2071, 2003.

    Google Scholar 

  76. Deslee G., Charbonnier A.-S., Hammad H., Angialosi G., Tille-Lebond I., et al., J Allergy Clin Immunol 110, 763–770, 2002.

    Google Scholar 

  77. Wollenberg A., Mommoas M., Oppel T., Schottdorf E.-M., Günther S., and Morderer M., J Invest Dermatol 118, 327–334, 2002.

    Google Scholar 

  78. Nguyen D.G. and Hildreth E.K., Eur J Immunol 33, 483–493, 2003.

    Google Scholar 

  79. Prigozy T.I., Sieling P.A., Clemens D., Stewart P.L., Behar S.M., et al., Immunity 6, 187–197, 1997.

    Google Scholar 

  80. Gummurulu S., Rogel M., Stamatatos L., and Enerman M., J Virol 77, 12865–12874, 2003.

    Google Scholar 

  81. Akira S., Takeda K., and Kaisho T., Nat Immunol 2, 675–680, 2001.

    Google Scholar 

  82. Equils O., Schito M.L., Karahashi H., Modak Z., Yarali A., Michelson K.S., Sher A., and Arditi M., J Immunol 170, 5159–5164, 2003.

    Google Scholar 

  83. Bafica A., Scanga C.A., Schito M.L., Hieny S., and Sher A., J Immunol 171, 1123–1127, 2003.

    Google Scholar 

  84. Lore´ K., Betts M.R., Brenchly J.M., Kuruppu J., Khojasteh S., Perfetto S., Roederer M., Seder R.A., and Koup R.A., J Immunol 171, 4320–4328, 2003.

    Google Scholar 

  85. Zheng L., Huang X.-L., Fan Z., Borowski L., Wilson C.C., and Rinaldo C.R., AIDS Res Human Retroviruses 15, 1011–1020, 1999.

    Google Scholar 

  86. An H., Yu Y., Zhang M., Xu H., Qi R., Yan X., et al., Immunology 106, 38–45, 2002.

    Google Scholar 

  87. Xie J., Qian J., Wang s., Freeman III M.E., Epstein J., and Yi Q., J Immunol 171, 4792–4800, 2003.

    Google Scholar 

  88. Kaisho T., Takeuchi D., Kawai T., Hoshino K., and Akira S., J Immunol 166, 5688–5694, 2001.

    Google Scholar 

  89. Jeamin P., Renno T., Goetsch L., Miconnet I., Aubry J.-P., et al., Nat Immunol 1, 502–509, 2000.

    Google Scholar 

  90. Montefiori D.C., Stewart K., Ahearn J.M., Zhou J., and Zhou J, J Virol 67, 2699–2706, 1993.

    Google Scholar 

  91. Cao X., Sugita M., Vander der Wel N., Lai J., Rogers R.A., Peters P.J., and Brenner M.B., J Immunol 169, 4770–4777, 2002.

    Google Scholar 

  92. Pena-Cruz V., Ito Dascher C.C., Brenner M.B., and Sugita M., J Invest Dermatol 121, 517–521, 2003.

    Google Scholar 

  93. Branch Moody B., Briken V., Cheng T.-Y., Roura-Mir C., Guy M.R., et al., Nat Immunol 3, 435–442, 2002.

    Google Scholar 

  94. Nishimura T., Kitamura H., Iwakabe K., Yahata T., Ohna A., et al., Int Immunol 12, 987–994, 2002.

    Google Scholar 

  95. Tsai C.-C., Emau P., Jiang Y., Tian B., Morton W.R., Gustafson K.R., and Boyd M.R., AIDS Res Human Retroviruses 19, 535–541, 2003.

    Google Scholar 

  96. Tsai C.-C., Emau P., Jiang Y., Agy M.B., Shattock R.J., Schmidt R.J., Morton W.R., Gustafson K.R., and Boyd M.R., AIDS Res Human Retroviruses 20, 11–18, 2004.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Virology, Faculty of Medicine, the Hebrew University of Jerusalem, P.O. Box 12272, Jerusalem, 91120, Israel

    Yechiel Becker

Authors
  1. Yechiel Becker
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Becker, Y. HIV-1 gp120 Binding to Dendritic Cell Receptors Mobilize the Virus to the Lymph Nodes, but the Induced IL-4 Synthesis by FcεRI+ Hematopoietic Cells Damages the Adaptive Immunity – a Review, Hypothesis, and Implications. Virus Genes 29, 147–165 (2004). https://doi.org/10.1023/B:VIRU.0000032797.43537.d3

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/B:VIRU.0000032797.43537.d3

Search

Navigation