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Beryllium(II) binding to ATP and ADP: Potentiometric determination of the thermodynamic constants and implications for in vivo toxicity

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Abstract

Highly toxic beryllium(II) is divalent metal ion with a high charge density, making it a potential target for binding to bio-molecules rich in O donor groups. In aqueous solution Be2+ binds to ATP and ADP to form 1:1 Be2+:ATP and Be2+:ADP complexes in relatively acidic media. At neutral pH the complex formed undergoes hydrolysis. Be2+ binding to ATP and ADP is much stronger than Ca2+ and Mg2+ binding. The high affinity of Be2+ toward ATP and ADP binding suggests a mechanism relevant to understanding the in vivo chemical toxicity of this metal.

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Authors and Affiliations

  1. Department of Chemistry, Duke University, Box 90346, Durham, NC, 27708-0346, USA

    Hakim Boukhalfa & Alvin L. Crumbliss

  2. Department of Pathology, Duke University Medical Center, Durham, NC, 27710, USA

    James G. Lewis

Authors
  1. Hakim Boukhalfa
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  2. James G. Lewis
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  3. Alvin L. Crumbliss
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Correspondence to Alvin L. Crumbliss.

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Boukhalfa, H., Lewis, J.G. & Crumbliss, A.L. Beryllium(II) binding to ATP and ADP: Potentiometric determination of the thermodynamic constants and implications for in vivo toxicity. Biometals 17, 105–109 (2004). https://doi.org/10.1023/B:BIOM.0000018359.25658.9c

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  • DOI: https://doi.org/10.1023/B:BIOM.0000018359.25658.9c

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