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Chronic Administration of Oren-gedoku-to (TJ15) Inhibits Ischemia-Induced Changes in Brain Indoleamine Metabolism and Muscarinic Receptor Binding in the Mongolian Gerbil

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Abstract

We examined the effect of Oren-gedoku-to (TJ15), which is a traditional herbal Kampo prescription used as an anti-cerebral apoplexy agent on these changes. Chronic pre- and post-ischemia TJ15 oral administration almost completely abolished the ischemia-induced muscarinic receptor reduction and 5-hydroxyindoleacetic acid level increase. These results suggest that TJ15 prevents cholinergic synaptic dysfunction and serotonergic presynaptic hyperactivity induced by transient ischemia.

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Authors and Affiliations

  1. Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, Okayama, 700, Japan

    Hideaki Kabuto, Masato Asanuma, Sakiko Nishibayashi, Motoyuki Iida & Norio Ogawa

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  1. Hideaki Kabuto
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  2. Masato Asanuma
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  3. Sakiko Nishibayashi
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  4. Motoyuki Iida
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  5. Norio Ogawa
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Kabuto, H., Asanuma, M., Nishibayashi, S. et al. Chronic Administration of Oren-gedoku-to (TJ15) Inhibits Ischemia-Induced Changes in Brain Indoleamine Metabolism and Muscarinic Receptor Binding in the Mongolian Gerbil. Neurochem Res 22, 33–36 (1997). https://doi.org/10.1023/A:1027369119224

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