Skip to main content
SpringerLink
Log in

Cadherins as Modulators of Angiogenesis and the Structural Integrity of Blood Vessels

  • Published:
Cancer and Metastasis Reviews Aims and scope Submit manuscript

Abstract

The endothelial cell adhesion molecules, neural- and vascular endothelial-cadherin play essential roles in the formation of stable and fully functional blood vessels. This commentary discusses the multiple functions of these two cadherins in angiogenesis and the maintenance of blood vessel structural integrity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Breier G, Breviario F, Caveda L, Berthier R, Schnurch H, Gotsch U, Vestweber D, Risau W, Dejana E: Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system. Blood 87: 630-641, 1996

    Google Scholar 

  2. Lampugnani MG, Dejana E: Interendothelial junction: structure, signalling and functional roles. Curr Opin Cell Biol 9: 674-682, 1997

    Google Scholar 

  3. Rowlands TM, Symonds JM, Farookhi R, Blaschuk OW: Cadherins: crucial regulators of structure and function in reproductive tissues. Rev Reprod 5: 53-61, 2000

    Google Scholar 

  4. Tanihara H, Sano K, Heimark RL, St John T, Suzuki S: Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. Cell Adhesion Commun 2: 15-26, 1994

    Google Scholar 

  5. Blaschuk OW, Pouliot Y, Holland PC: Identification of a conserved region common to cadherins and influenza strain A hemagglutinins. J Mol Biol 211: 679-682, 1990

    Google Scholar 

  6. Blaschuk OW, Sullivan R, David S, Pouliot Y: Identification of a cadherin cell adhesion recognition sequence. Dev Biol 139: 227-229, 1990

    Google Scholar 

  7. Williams E, Willams G, Gour BJ, Blaschuk OW, Doherty P: A novel family of cyclic peptide antagonists suggests that N-cadherin specificity is determined by amino acids that flank the HAV motif. J Biol Chem 275: 4007-4012, 2000

    Google Scholar 

  8. Alexander JS, Blaschuk OW, Haselton FR: An N-cadherin-like protein contributes to solute barrier maintenance in cultured endothelium. J Cell Physiol 156: 610-618

  9. Peluso JJ, Pappalardo A, Trolice MP: N-cadherinmediated cell contact inhibits granulosa cell apoptosis in a progesterone-independent manner. Endocrinology 137: 1196-1203, 1996

    Google Scholar 

  10. Wilby MJ, Muir EM, Fok-Seang J, Gour BJ, Blaschuk OW, Fawcett JW: N-cadherin inhibits Schwann cell migration on astrocytes. Mol Cell Neurosci 14: 66-84, 1999

    Google Scholar 

  11. Kemler R: From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion. Trends Genet 9: 317-321, 1993

    Google Scholar 

  12. Daniel JM, Reynolds AB: The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or α-catenin. Mol Cell Biol 15: 4819-4824, 1995

    Google Scholar 

  13. Provost E, Rimm DL: Controversies at the cytoplasmic face of the cadherin-based adhesion complex. Curr Opin Cell Biol 11: 567-572, 1999

    Google Scholar 

  14. Daniel J, Reynolds A: Tyrosine phosphorylation and cadherin/catenin function. Bioessays 19: 883-891, 1997

    Google Scholar 

  15. Corada M, Mariotti M, Thurston G, Smith K, Kunkel R, Brockhaus M, Lampugnani MG, Martin-Padura I, Stoppacciaro A, Ruco L, McDonald DM, Ward PA, Dejana E: Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo. Proc Natl Acad Sci USA 96: 9815-9820, 1999

    Google Scholar 

  16. Hordijk PL, Anthony E, Mul FPJ, Rientsma R, Oomen LCJM, Roos D: Vascular-endothelial-cadherin modulates endothelial monolayer permeability. J Cell Sci 112: 1915-1923, 1999

    Google Scholar 

  17. Gulino D, Delachanal E, Concord E, Genoux Y, Morand B, Valiron M-O, Sulpice E, Scaife R, Alemany M, Vernet T: Alteration of endothelial cell monolayer integrity triggers resynthesis of vascular endothelial cadherin. J Biol Chem 273: 29786-29793, 1998

    Google Scholar 

  18. Gotsch U, Borges E, Bosse R, Boggemeyer E, Simon M, Mossmann H, Vestweber D: VE-cadherin antibody accelerates neutrophil recruitment in vivo. J Cell Sci 110: 583-588, 1997

    Google Scholar 

  19. Salomon D, Ayalon O, Patel-King R, Hynes RO, Geiger B: Extrajunctional distribution of N-cadherin in cultured human endothelial cells. J Cell Sci 102: 7-17, 1992

    Google Scholar 

  20. Lampugnani MG, Corada M, Caveda L, Breviaro F, Ayalon O, Geiger B, Dejana E: The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, β-catenin, and α-catenin with vascular endothelial cadherin (VE-cadherin). J Cell Biol 129: 203-217, 1995

    Google Scholar 

  21. Blaschuk OW, Gour BJ: Compounds and methods for modulating cell adhesion. US patent 6,031,072, 2000

  22. Liaw CW, Tomaselli KJ, Cannon C, Davis K, Rubin L: Disruption of MDCK and bovine endothelial cell tight junctions with cadherin synthetic peptides. J Cell Biol 111: 408a, 1990

    Google Scholar 

  23. Matsuyoshi N, Toda K, HoriguchiY, Tanaka T, Nakagawa S, Takeichi M, Imamura S: In vivo evidence of the critical role of cadherin-5 in murine vascular integrity. Proc Ass Am Phys 109: 362-371, 1997

    Google Scholar 

  24. Roberts WG, Palade GE: Neovasculature induced by vascular endothelial growth factor is fenestrated. Cancer Res 57: 765-772, 1997

    Google Scholar 

  25. Dvorak HF, Brown LF, Detmar M, Dvorak AM: Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 146: 1029-1039, 1995

    Google Scholar 

  26. Benjamin LE, Golijanin D, Itin A, Pode D, Keshet E: Selective ablation of immature blood vessels in established human 5 tumors follows vascular endothelial growth factor withdrawl. J Clin Invest 103: 159-165, 1999

    Google Scholar 

  27. Hirschi KK, D'Amore PA: Pericytes in the microvasculature. Cardiovascular Res 32: 687-698, 1996

    Google Scholar 

  28. Benjamin LE, Hemo I, Keshet E: A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development 125: 1591-1598, 1998

    Google Scholar 

  29. Folkman J, D'Amore, PA: Blood vessel formation: what is its molecular basis? Cell 87: 1153-1155, 1996

    Google Scholar 

  30. Esser S, Lampugnani MG, Corada M, Dejana E, Risau W: Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells. J Cell Sci 111: 1853-1865, 1998

    Google Scholar 

  31. Blaschuk OW, Gour BJ, Farookhi R: Anovel cadherin antagonist (exherin) blocks human ovarian tumor growth in nude mice. Mol Biol Cell 10: 72a, 1999

    Google Scholar 

  32. Carmeliet P, Lampugnani M-G, Moons L, Brevario F, Compernolle V, Bono F, Balconi G, Spagnuolo R, Oosthuyse B, Dewerchin M, Zanetti A, Angellilo A, Mattot V, Nuyens D, Lutgens E, Clotman F, de Ruiter MC, Gittenberger-de Groot A, Poelmann R, Kupu F, Herbert J-M, Collen D, Dejana E: Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF mediated endothelial survival and angiogenesis. Cell 98: 147-157, 1999

    Google Scholar 

  33. Radice GL, Rayburn H, Matsunami H, Knudsen KA, Takeichi M, Hynes RO: Developmental defects in mouse embryos lacking N-cadherin. Dev Biol 181: 64-78, 1997

    Google Scholar 

  34. Liao F, Bassi R, Corada M, Dejana E, Bohlen P, Hicklin DJ: Monoclonal antibodies against VE-cadherin and VEGF-R2 distinctly modulate vascular permeability.Keystone symposium on experimental and clinical regulation of angiogenesis. Abstract 327, 2000

  35. Rahimi N, Kazlauskas: A role for cadherin-5 in regulation of vascular endothelial growth factor receptor 2 activity in endothelial cells. Mol Biol Cell 10: 3401-3407, 1999

    Google Scholar 

  36. Viollet C, Doherty P: CAMs and the FGF receptor: an interacting role in axonal growth. Cell Tissue Res 290: 451-455, 1997

    Google Scholar 

  37. Trolice MP, Pappalardo A, Peluso JJ: Basic fibroblast growth factor and N-cadherin maintain rat granulosa cell and ovarian surface epithelial cell viability by stimulating the tyrosine phosphorylation of the fibroblast growth factor receptors. Endocrinology 138: 107-113, 1997

    Google Scholar 

  38. Saffell JL, Williams EJ, Mason IJ, Walsh FS, Doherty P: Expression of a dominant negative FGF receptor inhibits axonal growth and FGF receptor phosphorylation stimulated by CAMs. Neuron 18: 231-242, 1997

    Google Scholar 

  39. Risau W: Mechanisms of angiogenesis. Nature 386: 671-674, 1997

    Google Scholar 

  40. Seghezzi G, Patel S, Ren CJ, Gualandris A, Pintucci G, Robbins ES, Shapiro RL, Galloway AC, Rifkin DB, Mignatti P: Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis. J Cell Biol 141: 1659-1673, 1998

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Divisions of Urology, McGill University, Montreal, Quebec, Canada

    Orest W. Blaschuk

  2. Surgical Research, Department of Surgery, McGill University, Montreal, Quebec, Canada

    Tracey M. Rowlands

Authors
  1. Orest W. Blaschuk
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tracey M. Rowlands
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Blaschuk, O.W., Rowlands, T.M. Cadherins as Modulators of Angiogenesis and the Structural Integrity of Blood Vessels. Cancer Metastasis Rev 19, 1–5 (2000). https://doi.org/10.1023/A:1026522216059

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1026522216059

Search

Navigation