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Anticholinesterase Mechanism as a Factor of Immunotoxicity of Various Chemical Compounds

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Abstract

Experiments on Wistar rats showed that acute poisoning with chemicals in a dose of 0.75 LD50 (dimethyl dichlorovinyl phosphate, sarin, VX substance, sulfur yperite, lewisite, tetraethyl lead, dichloroethane) inhibiting platelet acetylcholine esterase, α-naphthyl-AS-acetate esterase, and α-naphthyl-butyrate esterase suppressed T cell-mediated immune reactions.

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Authors and Affiliations

  1. Saratov Military Institute of Radiation, Chemical, and Biological Defense, Saratov State Medical University, Russia

    P. F. Zabrodskii, V. G. Germanchuk, V. F. Kirichuk, M. L. Nodel' & A. N. Aredakov

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  1. P. F. Zabrodskii
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  2. V. G. Germanchuk
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  3. V. F. Kirichuk
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  4. M. L. Nodel'
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  5. A. N. Aredakov
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Correspondence to P. F. Zabrodskii.

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Zabrodskii, P.F., Germanchuk, V.G., Kirichuk, V.F. et al. Anticholinesterase Mechanism as a Factor of Immunotoxicity of Various Chemical Compounds. Bulletin of Experimental Biology and Medicine 136, 176–178 (2003). https://doi.org/10.1023/A:1026327225739

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