Preparation and Investigation of Inclusion Complexes Containing Nifluminic Acid and Cyclodextrins

Abstract

Nifluminic acid (N) is a frequently used anti-inflammatory drug,but its poor aqueous solubility is a disadvantageous property. Inclusion complexation with cyclodextrinderivatives (CDs) affords a possibility to increase its solubility properties. For thispurpose, different CDs were used, primarily hydroxypropyl-β-CD (HP-β-CD), to prepareproducts by powder mixing or kneading in four molecular ratios. The dissolution and in vitromembrane diffusion of the products were investigated. The wetting angles of pure N andHP-β-CD and of the products, and the n-octanol/water partition coefficients were determined.The interaction, leading to complex formation between the components of the products was examined by thermoanalytical methods.