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Effect of Alcoholic Intoxication on Water Content and Activity of Na,K-ATPase and Ca-ATPase in Rat Brain

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Abstract

We studied the effect of 2-week alcohol intoxication on water exchange and activity of Na,K-ATPase and Ca-ATPase in rat brain. Alcohol intoxication increased water content in the brain due to cell hyperhydration. It is assumed that hyperhydration results from increased Na+ content in cells due to inhibition Na,K-ATPase activity, which in turn is caused by activation of lipid peroxidation under the effect of ethanol. A possible mechanism of Na,K-ATPase inhibition.

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Authors and Affiliations

  1. Department of Human and Animal Biochemistry and Physiology, USA

    T. N. Zamai, N. M. Titova, A. S. Zamai, O. S. Usol'tseva, O. V. Yulenkova & D. A. Shumkova

  2. Krasnoyarsk State University, USA

    T. N. Zamai, N. M. Titova, A. S. Zamai, O. S. Usol'tseva, O. V. Yulenkova & D. A. Shumkova

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  1. T. N. Zamai
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  2. N. M. Titova
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  3. A. S. Zamai
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  4. O. S. Usol'tseva
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  5. O. V. Yulenkova
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  6. D. A. Shumkova
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Zamai, T.N., Titova, N.M., Zamai, A.S. et al. Effect of Alcoholic Intoxication on Water Content and Activity of Na,K-ATPase and Ca-ATPase in Rat Brain. Bulletin of Experimental Biology and Medicine 134, 541–543 (2002). https://doi.org/10.1023/A:1022948709336

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