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GM1 Ganglioside Potentiates Trimethyltin-Induced Expression of Interleukin-1Beta and the Nerve Growth Factor in Reactive Astrocytes in the Rat Hippocampus: An Immunocytochemical Study

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Abstract

This study demonstrates potentiation by GM1 ganglioside treatment of trimethyltin (TMT) induced reactivity of astrocytes, and the expression of astroglial interleukin-lbeta (IL-1beta) and nerve growth factor (NGF) immunoreactivities in the rat hippocampus. GM1 treatment also results in an increase of the number of IL-1beta and NGF immunoreactive astrocytes. Both the intensity of gliosis and stimulation of IL-1beta and NGF expression in astrocytes mostly occurs in the regions of heaviest neurodegeneration in the hippocampus (CA4/CA3c and CA1). It is tempting to assume that enhancement of astroglial NGF expression by GM1 ganglioside may play a role in the protective action of GM1 against neurotoxic insult.

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  1. Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Science, 3 Pasteur St, 02093, Warszawa, Poland

    Barbara Oderfeld-Nowak & Malgorzata Zaremba

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  1. Barbara Oderfeld-Nowak
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  2. Malgorzata Zaremba
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Oderfeld-Nowak, B., Zaremba, M. GM1 Ganglioside Potentiates Trimethyltin-Induced Expression of Interleukin-1Beta and the Nerve Growth Factor in Reactive Astrocytes in the Rat Hippocampus: An Immunocytochemical Study. Neurochem Res 23, 443–453 (1998). https://doi.org/10.1023/A:1022482106152

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