Abstract
For the purpose of biological screening, a number of new quinoxalines have been synthesized via fluorine replacement in 2,3-disubstituted 6,7-difluoroquinoxaline 1,4-dioxides and their deoxygenated derivatives by reactions with dialkylamines, sodium azide, and sodium methoxide.
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REFERENCES
Nosova, E.V., Lipunova, G.N., Sidorova, L.P., and Charushin, V.N., Russ. J. Org. Chem., 2001, vol. 37, no. 8, pp. 1169-1176.
Kurasava, I., Takada, A., and Kim, H.S., J. Heterocycl. Chem., 1995, vol. 32, p. 1085.
Cheesman, G.W.H. and Cookson, R.F., The Chemistry of Heterocyclic Compounds, Weissberger, A. and Taylor, E.C., Eds., New York: Wiley Intersci., 1979, vol. 35.
Barlin, G.B. The Chemistry of Heterocyclic Compounds, Weissberger, A. and Taylor, E.C., Eds., New York: Wiley Intersci., 1982, vol. 41.
Francis, I., Landquist, I.K., Levi, A.A., Silk, I.A., and Thor, I.M., Biochem. J., 1956, no. 63, p. 455.
Valenta, I.R., Hoover, I.R.E., and Pagano, I.F.,Anti-microb. Agents Chemother., 1966, p. 453.
Haley, T.I., Flesher, A.V., and Komescu, A.V., Nature, 1959, no. 184, p. 198.
US Patent no.-635 971, 1971; Chem. Abstr., 1972, vol. 76, no. 99 708 r.
Boido, A., Vazzana, L., and Saratore, F., Farmaco, 1994, vol. 49, p. 97.
Monge, A., Palop, I.A., De Cerain, A.L., Senaedor, V., Martinez-Crespo, F.I., Sainz, I., Narro, S., Garica, E., De Miquel, C., Gonzalez, M., Hamilton, E., Barker, A.I., Clarke, E.D., and Greenhow, D.T., J. Med. Chem., 1995, vol. 38, p. 1786.
Bouzard, D., Antibiotics and Antiviral Compounds. Chemical Synthesis and Modification, Krohn, R., Kirst, H.A., and Maag, H., Eds., Weinheim: VCH, 1993, pp. 187-203.
Granik, V.G., Lekarstva (Medicines), Moscow: Vuzovskaya Kniga, 2001, pp. 135-254.
Evans, T.A. and Seddon, K.R., J. Chem. Soc., Chem. Commun., 1997, vol. 21, p. 2023.
Kotovskaya, S.K., Charushin, V.N., Chupakhin, O.N., and Kozhevnikova, E.O., Russ. J. Org. Chem., 1998, vol. 34, no. 3, pp. 369-374.
Kotovskaya, S.K., Perova, N.M., Charushin, V.N., and Chupakhin, O.N., Mendeleev Commun., 1999, no. 2, pp. 76-77.
Chupakhin, O.N., Kotovskaya, S.K., Perova, N.M., Baskakova, Z.M., and Charushin, V.N., Khim. Geterotsikl. Soedin., 1999, no. 4, pp. 520-531.
Chupakhin, O.N., Kotovskaya, S.K., Perova, N.M., and Charushin, V.N., Mendeleev Commun., 2001, no. 2, pp. 54-56.
Charushin, V.N., Mokrushina, G.A., and Tkachev, A.V., J. Fluorine Chem., 2001, vol. 107, pp. 71-80.
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Kotovskaya, S.K., Romanova, S.A., Charushin, V.N. et al. Fluorine-Containing Heterocycles: VII. Nucleophilic Substitution in 6,7-Difluoroquinoxalines. Russian Journal of Organic Chemistry 38, 1046–1052 (2002). https://doi.org/10.1023/A:1020870100148
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DOI: https://doi.org/10.1023/A:1020870100148