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Two‐Color Laser Photodynamic Therapy of Tumors

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Journal of Applied Spectroscopy Aims and scope

Abstract

A method of photodynamic therapy of tumors (neoplasms) based on simultaneous action of radiation from two lasers with different generation wavelengths is proposed and implemented in an experiment on animals. The antineoplastic effect was evaluated by the dimensions of the necrosis region determined using the method of vital staining of tissues. The effect of photodynamic therapy in the case of simultaneous use of the two lasers (λ1 = 627.8 nm and λ2 = 671 nm) turned out to be higher than in the case of their separate application. The hypothetical reason for the phenomenon is oxyhemoglobin photodissociation that leads to the enrichment of blood with free oxygen.

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Authors and Affiliations

  1. Institute of Molecular and Atomic Physics, National Academy of Sciences of Belarus, 70 F. Skorina Ave., Minsk, 220072, Belarus

    B. M. Dzhagarov

  2. Institute of Oncology and Medicinal Radiology, N. N. Aleksandrov Scientific‐Research, Minsk, Belarus

    É. A. Zhavrid, Yu. P. Istomin & V. N. Chalov

Authors
  1. B. M. Dzhagarov
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  2. É. A. Zhavrid
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  3. Yu. P. Istomin
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  4. V. N. Chalov
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Dzhagarov, B.M., Zhavrid, É.A., Istomin, Y.P. et al. Two‐Color Laser Photodynamic Therapy of Tumors. Journal of Applied Spectroscopy 68, 201–204 (2001). https://doi.org/10.1023/A:1019255817114

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  • DOI: https://doi.org/10.1023/A:1019255817114

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