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Synthesis of 8-(3-Carboxy-l-methyl-propylammo)-6-methoxyquinoline: A Newly Characterized Primaquine Metabolite

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Abstract

Primaquine (I), a 6-methoxy-8-aminoqumoline derivative used for the treatment of malaria has previously been shown to be metabolized to 8-(3-carboxy-l-methyl-propylamino)-6-methoxyquinoline by both micro-organisms and laboratory rats. Reported herein is the synthesis of this novel metabolite.

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Authors and Affiliations

  1. The Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS, 38677

    James D. McChesney & Srinivasan Sarangan

Authors
  1. James D. McChesney
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  2. Srinivasan Sarangan
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McChesney, J.D., Sarangan, S. Synthesis of 8-(3-Carboxy-l-methyl-propylammo)-6-methoxyquinoline: A Newly Characterized Primaquine Metabolite. Pharm Res 1, 96–98 (1984). https://doi.org/10.1023/A:1016311616719

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  • DOI: https://doi.org/10.1023/A:1016311616719

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