Abstract
The antifungal activity of five new synthetic compounds was evaluated on two dermatophytes: Epidermophyton floccosum and Trichophyton rubrum. The data showed that the imidazo-pyrazole and pyrazolo-thiazoles were not particularly effective, while the two pyrazole-thiocyanates proved highly active on both fungi. The most active 5-amino-3-methyl-1-phenylpyrazolo-4-thiocyanate was chosen to perform SEM and TEM morphological studies on both fungi. Both SEM and TEM observations revealed interesting alterations on the two dermatophytes, particularly involving the endomembrane system.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Vicentini CB, Ferretti V, Veronese AC, Guarneri M, Manfrini M, Giori P. Synthesis of 6-substituted imidazo[4,5-c]pyrazole-5-thiones Heterocycles 1995; 41: 497–506.
Vicentini CB, Veronese AC, Guarneri M, Manfrini M, Giori P. A new synthesis of pyrazolo[3,4-d]thiazoles Heterocycles 1993; 36: 857–863.
Giori P, Vertuani G, Mazzotta D, Guarneri M, Pancaldi D, Brunelli A, Kovacs A. Derivati di tiociano pirazolo quali fitofarmaci, ad azione fungicida, in particolare antiperonosporica, e relativi metodi di preparazione; Italian Patent 20866. 1982.
Vicentini CB, Brandolini V, Poli T, Guarneri M, Giori P. Fungitoxicity of 5-aminoisoxazole-4-thiocyanate derivatives Pestic Sci 1992; 34: 127–131.
Romagnoli C, Vicentini CB, Mares D. Antifungal effects of the 3-methyl-5-aminoisoxazole-4-thiocyanate on some dermatophytes Lett Appl Microbiol 1995; 20: 5–6.
Mares D, Romagnoli C, Sacchetti G, Vicentini CB, Bruni A. Alterations in spore production in Trichophyton rubrum treated in vitro with 1-amino-6-methyl-4-phenylpyrazolo [3,4-d]-1,2,3-triazole Mycoses 1999; 42: 549–554.
Vanden Bossche H. Importance and role of sterols in fungal membranes. In Kuhn PJ, Trinci AJ, Jung MJ, Goosey MW, Copping LG eds. Biochemistry of Cell Walls and Membranes in Fungi, Springer-Verlag 1990: 135–153.
Vanden Bossche H, Marichal P. Azole antifungal: mode of action. In Yamaguchi H, Kobayashi GS, Takahashi H. eds. Recent Progress in Antifungal Chemotherapy. Dekker Inc, New York 1992: 25–40.
Borgers M. Antifungal azole derivatives. In O'Grady D, O'Grady F. eds. Symposium of the Society for General Microbiology. Scientific basis of Antimicrobial chemotherapy, Cambridge University Press: London. 1985: 133–153.
Gupta GD, Heath IB. Actin disruption by latrunculin B causes turgor-related changes in tip growth of Saprolegnia ferax hyphae. Fungal Genet Biol 1997; 21: 64–75.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Romagnoli, C., Mares, D., Bruni, A. et al. Antifungal activity of 5 new synthetic compounds vs. Trichophyton rubrum and Epidermophyton floccosum . Mycopathologia 153, 129–132 (2002). https://doi.org/10.1023/A:1014593416665
Issue Date:
DOI: https://doi.org/10.1023/A:1014593416665